RT Journal Article
T1 Discrepancies in the RIFLE classification are due to the method used to assess the level of derangement of kidney function
A1 Herrera-Gutiérrez, Manuel Enrique
A1 Seller Pérez, Gemma Luisa
A1 Banderas Bravo, Esther
A1 Aragón González, César
A1 Olalla Sánchez, Rebeca
A1 Lozano-Sáez, Rosario
K1 Insuficiencia renal aguda
K1 Creatinina
AB Purpose: We hypothesized that RIFLE based on creatinine clearance (CrCl) is superior to that based on serum creatinine (sCr) or Cockroft-Gault (C-G) because it is an earlier marker of kidney dysfunction.Materials and methods: At day 3 of admission, we compared the RIFLE based on sCr, C-G, and CrCl with 28-day mortality and development of RIFLE-F during intensive care unit stay.Results: Percentages in the RIFLE levels were similar for the 3 estimates, but the patients included in each level were different; with CrCl as the reference, κ statistic was 0.29 (95% confidence interval, 0.15-0.43) for sCr and 0.21 (0.07-0.36) for C-G. Mortality at day 28 was 19.3%, with percentages of mortality increasing with RIFLE based in CrCl but not sCr or C-G (area under the curve, 0.57 [45-72] for C-G; 0.57 [44-72] for sCr; and 0.64 [52-79] for CrCl). Logistic regression only showed an independent relationship with mortality for RIFLE measured with CrCl.Conclusions: RIFLE classification using sCr or C-G at the third day of admission predicts outcome less accurately than with the use of CrCl. Because of the delay in the rise of sCr after a sudden glomerular filtration rate decrease, RIFLE based in CrCl may represent an advantage in terms of precocity
PB Elsevier
YR 2011
FD 2011-12
LK https://hdl.handle.net/10630/41166
UL https://hdl.handle.net/10630/41166
LA eng
NO Herrera-Gutiérrez ME, Seller-Pérez G, Banderas-Bravo E, Aragón-Gonzalez C, Olalla-Sánchez R, Lozano-Sáez R. Discrepancies in the RIFLE classification are due to the method used to assess the level of derangement of kidney function. J Crit Care. 2011 Dec;26(6):572-6. doi: 10.1016/j.jcrc.2011.02.006. Epub 2011 Mar 24. PMID: 21439764. Copy  Download .nbib
NO https://openpolicyfinder.jisc.ac.uk/id/publication/4780
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026