RT Journal Article
T1 Increased levels of serum surfactant protein D are associated with cardiovascular disease incidence in the Spanish adult population: Di@bet.es study
A1 Oualla-Bachiri, Wasima
A1 Lago-Sampedro, Ana
A1 García-Escobar, Eva
A1 Maldonado- Araque, Cristina
A1 Delgado, Elías
A1 Chaves, Felipe J.
A1 Castaño, Luis
A1 Calle-Pascual, Alfonso
A1 Franch-Nadal, Josep
A1 Olveira-Fuster, Gabriel María
A1 Rojo-Martínez, Gemma
A1 Doulatram- Gamgaram, Viyey
A1 Valdés, Sergio
K1 Sistema cardiovascular - Enfermedades
K1 Marcadores bioquímicos
K1 Corazón - Enfermedades
K1 Tabaquismo
AB Cardiovascular disease (CVD) remains the leading cause of mortality. New biomarkers are needed to improve CVD risk prediction. Several studies have reported associations between surfactant protein D (SP-D), an innate immune system component, and CVD; however, general population studies remain scarce. The main aim of this study was to investigate the association between SP-D and CVD events incidence in the Spanish general adult population.MethodsSocio-demographic, lifestyle (including smoking status) and clinical data from 1707 participants of the di@bet.es cohort without previous CVD events were collected and analysed. CVD events (including both morbidity and mortality) were reported at baseline and after 7.5 years of follow-up. SP-D serum levels were measured by ELISA and categorized in quartiles.ResultsSP-D categories are associated with CVD events incidence, independently from other strong risk factors such as cardiovascular risk scores (SCORE2 and SCORE2-OP), BMI, hs-CRP, or eGFR. Although SP-D has been linked to smoking, SP-D categories predicted CVD events incidence even among non-smokers. The addition of SP-D to multivariate models improved performance in the assessment, predicting 83% of the events with a specificity of 74% and a sensitivity of 84% in the overall population.ConclusionsSP-D may be considered as a promising biomarker of CVD events in combination with other well established factors in clinical practice.
PB Wiley
YR 2026
FD 2026
LK https://hdl.handle.net/10630/45395
UL https://hdl.handle.net/10630/45395
LA eng
NO Oualla-Bachiri W, Lago-Sampedro A, García-Escobar E, et al. Increased levels of serum surfactant protein D are associated with cardiovascular disease incidence in the Spanish adult population: Di@bet.es study. Eur J Clin Invest. 2026; 56:e70179. doi:10.1111/eci.70179
NO Funding for open access charge: Universidad de Málaga / CBUA
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 4 mar 2026