RT Journal Article
T1 Evidence from cyclostomes for complex regionalization of the ancestral vertebrate brain.
A1 Sugahara, Fumiaki
A1 Pascual-Anaya, Juan
A1 Oisi, Yasuhiro
A1 Kuraku, Shigehiro
A1 Aota, Shin-ichi
A1 Adachi, Noritaka
A1 Takagi, Wataru
A1 Hirai, Tamami
A1 Murakami, Yasunori
A1 Kuratani, Shigeru
K1 Cerebro - Evolución
K1 Lampreas
AB The vertebrate brain is highly complex, but its evolutionary origin remains elusive. Because of the absence of certain developmental domains generally marked by the expression of regulatory genes, the embryonic brain of the lamprey, a jawless vertebrate, had been regarded as representing a less complex, ancestral state of the vertebrate brain. Specifically, the absence of a Hedgehog- and Nkx2.1-positive domain in the lamprey subpallium was thought to be similar to mouse mutants in which the suppression of Nkx2-1 leads to a loss of the medial ganglionic eminence. Here we show that the brain of the inshore hagfish (Eptatretus burgeri), another cyclostome group, develops domains equivalent to the medial ganglionic eminence and rhombic lip, resembling the gnathostome brain. Moreover, further investigation of lamprey larvae revealed that these domains are also present, ruling out the possibility of convergent evolution between hagfish and gnathostomes. Thus, brain regionalization as seen in crown gnathostomes is not an evolutionary innovation of this group, but dates back to the latest vertebrate ancestor before the divergence of cyclostomes and gnathostomes more than 500 million years ago.
PB Nature Research
YR 2016
FD 2016
LK https://hdl.handle.net/10630/33836
UL https://hdl.handle.net/10630/33836
LA eng
NO Sugahara, F., Pascual-Anaya, J., Oisi, Y. et al. Evidence from cyclostomes for complex regionalization of the ancestral vertebrate brain. Nature 531, 97–100 (2016). https://doi.org/10.1038/nature16518
NO https://v2.sherpa.ac.uk/id/publication/4008
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 21 ene 2026