RT Conference Proceedings
T1 Stress, depression and the hippocampus: modulatory effects of continuous LPA treatment
A1 Moreno-Fernández, Román D.
A1 Bacq, Alexandre
A1 Rosell-del-Valle, Cristina
A1 Zanoletti, Olivia
A1 Cifuentes-Rueda, Manuel
A1 Pérez-Martín, Margarita
A1 García-Fernández, María Inmaculada
A1 Estivill-Torrús, Guillermo
A1 Rodriguez-de-Fonseca, Fernando
A1 Santín-Núñez, Luis Javier
A1 Sandi, Carmen
A1 Pedraza-Benítez, María del Carmen
K1 Estrés emocional
K1 Hipocampo (Cerebro) - Congresos
AB The LPA1, one of the six characterized G protein-coupled receptors (LPA1–6) through which lysophosphatidic acid acts may be involved in promoting normal emotional behaviors. Evidence also imply a role for the LPA1 receptor in mediating the consequences of stress on the hippocampus. However, to date, there is not available information regarding the mechanisms whereby the LPA1 receptor mediates this adaptation. Changes in glutamate/GABA cycling could be one possible mechanism. To gain further insight into how LPA-LPA1 may prevent the negative consequences of chronic stress, we assessed the effects of chronic ICV administration of LPA on depressive-like behaviours induced by a chronic restraint stress protocol. Then, gene expression for molecular markers for excitatory and inhibitory neurotransmission was determined. In addition, the hippocampal expression of mineralocorticoid receptor and glucocorticoid receptor genes and proteins were determined, as well as plasma corticosterone levels. Contrary to expectations, the continuous delivery of LPA in chronically stressed animals instead of inhibiting, potentiated some, though not all, negative effects of stress. Furthermore, this treatment induced as well altered the excitatory/inhibitory balance in the ventral hippocampus. In conclusion, the results of this study reinforce the assumption that LPA, mainly through the LPA1 receptor, regulates hippocampal-dependent behaviour and functions.
YR 2019
FD 2019-06-25
LK https://hdl.handle.net/10630/17873
UL https://hdl.handle.net/10630/17873
LA eng
NO Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.Funding: This study was supported by Consejería de Economía, Innovación, Ciencia y Empleo, Junta de Andalucía (SEJ1863 to C.P.; CTS-643 to G.E.-T), Ministerio de Economía y Competitividad and the European Regional Development Fund (PSI2017-83408-P to C.P.), Consejería de Salud de la Junta de Andalucía (NICOLÁS MONARDE Program to G.E:T) Ministerio de Educación, Cultura y Deporte (FPU14/01610 to R.D.M.-F.; FPDI2010 to C.R-V. (Junta de Andalucía) and intramural funding from the EPFL to C.S. I Plan propio de investigación y transferencia de la Universidad de Málaga (Congress attendance of C.P).
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 21 ene 2026