RT Journal Article
T1 Galanin (1–15) enhances the antidepressant effects of the 5-HT1A receptor agonist 8-OH-DPAT: involvement of the raphe-hippocampal 5-HT neuron system
A1 Millón-Peñuela, Carmelo
A1 Flores-Burgess, Antonio
A1 Narváez-Peláez, Manuel
A1 Borroto Escuela, Dasiel Óscar
A1 Santín-Núñez, Luis Javier
A1 Gago-Calderón, Belén
A1 Narváez-Bueno, José Ángel
A1 Fuxe, Kjell
A1 Díaz-Cabiale, Zaida
K1 Depresión mental
K1 Neuropéptidos
K1 Antidepresivos
AB Galanin N-terminal fragment (1–15) [GAL(1–15)] is associated with depression-related and anxiogenic-like effects in rats. In this study, we analyzed the ability of GAL(1–15) to modulate 5-HT1A receptors (5-HT1AR), a key receptor in depression. GAL(1–15) enhanced the antidepressant effects induced by the 5-HT1AR agonist 8-OH-DPAT in the forced swimming test. These effects were stronger than the ones induced by Galanin (GAL). This action involved interactions at receptor level since GAL(1–15) affected the binding characteristics and the mRNA levels of 5-HT1AR in the dorsal hippocampus and dorsal raphe. The involvement of the GALR2 was demonstrated with the GALR2 antagonist M871. Proximity ligation assay experiments indicated that 5-HT1AR are in close proximity with GALR1 and GALR2 in both regions and in raphe RN33B cells. The current results indicate that GAL(1–15) enhances the antidepressant effects induced by 8-OH-DPAT acting on 5-HT1AR operating as postjunctional or as autoreceptors. These results may give the basis for the development of drugs targeting potential GALR1–GALR2–5-HT1AR heteroreceptor complexes linked to the raphe-hippocampal 5-HT neurons for the treatment of depression.
PB Springer Nature
SN 1863-2653
YR 2016
FD 2016-01-20
LK https://hdl.handle.net/10630/33174
UL https://hdl.handle.net/10630/33174
LA eng
NO Millón, C., Flores-Burgess, A., Narváez, M. et al. Galanin (1–15) enhances the antidepressant effects of the 5-HT1A receptor agonist 8-OH-DPAT: involvement of the raphe-hippocampal 5-HT neuron system. Brain Struct Funct 221, 4491–4504 (2016).
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 25 ene 2026