RT Journal Article T1 Selenium bioaccesibility after in vitro digestion/fermentation of foods differs in adults and children. A1 García-Conde, Úrsula A1 Navarro-Alarcón, Miguel A1 Navajas Porras, Beatriz A1 Hinojosa-Nogueira, Daniel A1 Delgado-Osorio, Adriana A1 Navarro-Moreno, Miguel A1 Pérez-Burillo, Sergio A1 Pastoriza, Silvia A1 Douros, Konstantinos A1 Rufián-Henares, José Ángel K1 Selenio K1 Alimentos K1 Biodisponibilidad K1 Intestinos K1 Adultos K1 Niños AB Selenium (Se) as essential element regulates the immune, endocrine, reproductive and neurological systemsthrough selenoproteins. More important than its content, is the fraction available to be absorbed (bioaccesibility)to exert its important metabolic functions. The objective of this study was to determine the bioaccessibility of Se(Se-BA) in multiple foods by an in vitro digestion/fermentation method. Samples were subjected to homemadeculinary techniques and fermented with feces from healthy adults (HE-AD), and healthy (HE-CH) and unhealthychildren (with gluten related disorders, GRD-CH; obesity, OB-CH; or allergy/intolerance to cow’s milk proteins,AICM-CH). Se-BA varied largely among samples depending on their vegetal/animal origin, category and type offood. Animal-vs. plant-based foods have higher mean Se concentration and total Se-BA (82.5(±97.5) and 93.6(±8.58) vs. 44.3(±55.6) μg/kg and 77.7(±20.4)%, respectively). In plant-based foods, higher Se-BA values werefound in the large intestine (41.0(±25.7) vs. 30.1(±26.7%) in animal-base foods). In comparison to raw foods,the cooking techniques of vegetal- and animal-based foods grouped by heating in liquid media (frying-boiling) orhot air (roasting-grilling) decrease Se-BA in the small intestine (42.5(±27.0) vs. 34.8(±25.1) and 34.0(±24.3),and 75.9(±38.0) vs. 52.4(±28.9) and 71.3(±24.8)%, respectively), while it is increased in the large intestine(36.6(±28.5) vs. 41.3(±24.9) and 44.2(±23.6), and 19.9(±30.4) vs. 39.9(±26.0) and 23.4(±22.7)%, respectively). The higher Se-BA levels in the large intestine found in HE-CH (42.1 (±26.5) vs. HE-AD (35.2(±27.1) andunhealthy children (GRD-CH and OB-CH; 38.0(±24.6) and 35.8(±28.1)%, respectively) could be related togreater demands on growth and specific fermentative microbiota. PB Elsevier YR 2024 FD 2024-03-25 LK https://hdl.handle.net/10630/38628 UL https://hdl.handle.net/10630/38628 LA eng NO García-Conde Ú, Navarro-Alarcón M, Navajas-Porras B, Hinojosa-Nogueira D, Delgado-Osorio A, Navarro-Moreno M, et al. Selenium bioaccesibility after in vitro digestion/fermentation of foods differs in adults and children. Food Biosci. 2024;59:103964. DS RIUMA. Repositorio Institucional de la Universidad de Málaga RD 21 ene 2026