RT Journal Article
T1 Synthesis of all-aliphatic polyamide dendrimers based on a 3,3′-diaminopivalic acid scaffold.
A1 Ruiz-Sánchez, Antonio Jesús
A1 Mesa-Antúnez, Pablo
A1 Barbero, Nekane
A1 Collado-Martín, Daniel
A1 Vida-Pol, Yolanda
A1 Nájera-Albendín, Francisco
A1 Pérez-de-Inestrosa-Villatoro, Ezequiel
K1 Dendrímeros
K1 Poliamidas
AB Over recent years the importance of dendrimers has continued to increase in both life and material sciences. Multiple chemical strategies have been described toward the preparation of dendrimeric structures. Here, we present a new approach for the production of all-aliphatic polyamide dendrimers. In our approach, iterative 3,3′-diaminopivalic acid connections act as building blocks for dendrimer construction. 3,3′-Diazidopivalic acid units underpin a two-step pathway involving carboxylic acid–amine condensation, followed by azide reduction. The carboxylic acid–amine condensation step can be carried out by conventional methods, while the hydrogen-catalyzed azide-to-amine reduction is a clean process particularly appropriate for dendrimer preparation. Spectroscopic characterization of functionalized surface azides (Gn-N3) and amines (Gn-NH2) confirm the proposed structures. These dendrimers were studied in explicit solvent by atomistic forcefield-based molecular dynamics to characterize structural properties such as shape, radius and monomer distribution. Our results show that these compounds are similar in size and shape, with Gn-NH2 having a slightly bigger size and exhibiting lower terminal unit backfolding.
PB RSC publication
SN 1759-9954
YR 2015
FD 2015-03-09
LK https://hdl.handle.net/10630/33251
UL https://hdl.handle.net/10630/33251
LA eng
NO Ruiz-Sanchez, A. J., Mesa-Antunez, P., Barbero, N., Collado, D., Vida, Y., Najera, F., & Perez-Inestrosa, E. (2015). Synthesis of all-aliphatic polyamide dendrimers based on a 3,3′-diaminopivalic acid scaffold. Polymer Chemistry, 6(16), 3031–3038.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026