RT Journal Article
T1 Multiple sclerosis iPS-derived oligodendroglia conserve their properties to functionally interact with axons and glia in vivo
A1 Mozafari, Sabah
A1 Starost, Laura
A1 Manot Saillet, Blandine
A1 Garcia Diaz, Beatriz
A1 Xu, Yu Kang T
A1 Roussel, Delphine
A1 Levy, Marion J F
A1 Ottoboni, Linda
A1 Kim, Kee Pyo
A1 Scholer, Hans R
A1 Kennedy, Timothy E
A1 Antel, Jack P
A1 Martino, Gianvito
A1 Angulo, Maria Cecilia
A1 Kulmann, Tanja
A1 Baron Van Evercooren, Anne
A1 martino, 
K1 Esclerosis múltiple
AB Remyelination failure in multiple sclerosis (MS) is associated with a migration/differentiation block of oligodendroglia. The reason for this block is highly debated. It could result from disease-related extrinsic or intrinsicregulators in oligodendroglial biology. To avoid confounding immune-mediated extrinsic effect, we used animmune-deficient mouse model to compare induced pluripotent stem cell–derived oligodendroglia from MS andhealthy donors following engraftment in the developing CNS. We show that the MS-progeny behaves and differentiates into oligodendrocytes to the same extent as controls. They generate equal amounts of myelin, with bonafide nodes of Ranvier, and promote equal restoration of their host slow conduction. MS-progeny expressedoligodendrocyte- and astrocyte-specific connexins and established functional connections with donor and host glia.Thus, MS oligodendroglia, regardless of major immune manipulators, are intrinsically capable of myelinationand making functional axo-glia/glia-glia connections, reinforcing the view that the MS oligodendrocyte differentiation block is not from major intrinsic oligodendroglial deficits.
PB American Association for the Advancement of Science
YR 2020
FD 2020
LK https://hdl.handle.net/10630/32324
UL https://hdl.handle.net/10630/32324
LA eng
NO Sabah Mozafari et al. ,Multiple sclerosis iPS-derived oligodendroglia conserve their properties to functionally interact with axons and glia in vivo.Sci. Adv.6,eabc6983(2020).DOI:10.1126/sciadv.abc6983
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 13 abr 2026