RT Journal Article
T1 A Defense Pathway Linking Plasma Membrane and Chloroplasts and Co-opted by Pathogens
A1 Medina-Puche, Laura
A1 Tan, Huang
A1 Vivek Dogra, 
A1 Wu, Mengshi
A1 Rosas-Díaz, Tábata Victoria
A1 Liping, Wang
A1 Xue, Ding
A1 Dan, Zhanga
A1 Xing Fu, 
A1 Chanhong Kim, 
A1 Lozano-Durán, Rosa
K1 Virus fitopatógenos
AB Chloroplasts are crucial players in the activation of defensive hormonal responses during plant-pathogen interactions. Here, we show that a plant virus-encoded protein re-localizes from the plasma membrane to chloroplasts upon activation of plant defense, interfering with the chloroplast-dependent anti-viral salicylic acid (SA) biosynthesis. Strikingly, we have found that plant pathogens from different kingdoms seem to have convergently evolved to target chloroplasts and impair SA-dependent defenses following an association with membranes, which relies on the co-existence of two subcellular targeting signals, an N-myristoylation site and a chloroplast transit peptide. This pattern is also present in plant proteins, at least one of which conversely activates SA defenses from the chloroplast. Taken together, our results suggest that a pathway linking plasma membrane to chloroplasts and activating defense exists in plants and that such pathway has been co-opted by plant pathogens during host-pathogen co-evolution to promote virulence through suppression of SA responses.
PB Elsevier
YR 2020
FD 2020-07
LK https://hdl.handle.net/10630/34262
UL https://hdl.handle.net/10630/34262
LA spa
NO Laura Medina-Puche, Huang Tan, Vivek Dogra, Mengshi Wu, Tabata Rosas-Diaz, Liping Wang, Xue Ding, Dan Zhang, Xing Fu, Chanhong Kim, Rosa Lozano-Duran, A Defense Pathway Linking Plasma Membrane and Chloroplasts and Co-opted by Pathogens, Cell, Volume 182, Issue 5, 2020, Pages 1109-1124.e25, ISSN 0092-8674, https://doi.org/10.1016/j.cell.2020.07.020.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026