RT Journal Article
T1 One-year longitudinal association between changes in dietary choline or betaine intake and cardiometabolic variables in the PREvención con DIeta MEDiterránea-Plus (PREDIMED-Plus) trial.
A1 Díez-Ricote, Laura
A1 San-Cristobal, Rodrigo
A1 Consejo, M Jose
A1 Martínez González, Miguel Ángel
A1 Corella, Dolores
A1 Salas-Salvadó, Jordi
A1 Goday, Albert
A1 Martínez, J Alfredo
A1 Alonso Gómez, Ángel M
A1 Warnberg, Julia
A1 Vioqué, Jesús
A1 Romaguera, Dora
A1 López-Miranda, José
A1 Estruch, Ramón
A1 Tinahones-Madueño, Francisco José
A1 Lapetra, José
A1 Serra-Majem, Lluís
A1 Bueno-Cavanillas, Aurora
A1 Tur, Josep A
A1 Martín-Sánchez, Vicente
A1 Pintó, Xavier
A1 Gaforio, José J
A1 Matía-Martín, Pilar
A1 Vidal, Josep
A1 Mas Fontao, Sebastián
A1 Ros, Emilio
A1 Vázquez-Ruiz, Zenaida
A1 Ortega-Azorín, Carolina
A1 García-Gavilán, Jesús F
A1 Malcampo, Mireia
A1 Martínez-Urbistondo, Diego
A1 Tojal-Sierra, Lucas
A1 García-Rodríguez, Antonio
A1 Gómez-Belvert, Nuria
A1 Chaplin, Alice
A1 García-Rios, Antonio
A1 Bernañ-López, Rosa M
A1 Santos-Lozano, José M
A1 Basterra-Gortari, Javier
A1 Sorli, José V
A1 Murphy, Michelle
A1 Gasulla, Griselda
A1 Micó, Victor
A1 Salaverria-Lete, Itziar
A1 Goñi Ochandorena, Estibaliz
A1 Babio, Nancy
A1 Herraiz, Xavier
A1 Ordovás, José M
A1 Daimiel, Lidia
K1 Aparato circulatorio
K1 Dietética
AB Background: Choline and betaine intakes have been related tocardiovascular health.Objectives: We aimed to explore the relation between 1-y changesin dietary intake of choline or betaine and 1-y changes incardiometabolic and renal function traits within the frame of thePREDIMED (PREvención con DIeta MEDiterránea)-Plus trial.Methods: We used baseline and 1-y follow-up data from 5613participants (48.2% female and 51.8% male; mean ± SD age:65.01 ± 4.91 y) to assess cardiometabolic traits, and 3367participants to assess renal function, of the Spanish PREDIMEDPlustrial. Participants met ≥3 criteria of metabolic syndrome andhad overweight or obesity [BMI (in kg/m2) ≥27 and ≤40]. Thesecriteria were similar to those of the PREDIMED parent study.Dietary intakes of choline and betaine were estimated from theFFQ.Results: The greatest 1-y increase in dietary choline or betaineintake (quartile 4) was associated with improved serum glucoseconcentrations (−3.39 and −2.72 mg/dL for choline and betaine,respectively) and HbA1c levels (−0.10% for quartile 4 of eithercholine or betaine intake increase). Other significant changesassociated with the greatest increase in choline or betaine intakewere reduced body weight (−2.93 and −2.78 kg, respectively), BMI(−1.05 and −0.99, respectively), waist circumference (−3.37 and−3.26 cm, respectively), total cholesterol (−4.74 and −4.52 mg/dL,respectively), and LDL cholesterol (−4.30 and −4.16 mg/dL,respectively). Urine creatinine was reduced in quartile 4 of 1-yincrease in choline or betaine intake (−5.42 and −5.74 mg/dL,respectively).Conclusions: Increases in dietary choline or betaine intakeswere longitudinally related to improvements in cardiometabolicparameters. Markers of renal function were also slightly improved,and they require further investigation. This trial was registered athttps://www.isrctn.com/ as ISRCTN89898870. Am J Clin Nutr2022;116:1565–1579.
PB Oxford University Press
YR 2022
FD 2022
LK https://hdl.handle.net/10630/36782
UL https://hdl.handle.net/10630/36782
LA eng
NO Laura Díez-Ricote... [et al.]. One-year longitudinal association between changes in dietary choline or betaine intake and cardiometabolic variables in the PREvención con DIeta MEDiterránea-Plus (PREDIMED-Plus) trial, The American Journal of Clinical Nutrition, Volume 116, Issue 6, December 2022, Pages 1565–1579, [https://doi.org/10.1093/ajcn/nqac255]
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026