RT Journal Article
T1 Effect of Cenobamate on Cognition in Patients with Drug‑Resistant Epilepsy with Focal Onset Seizures: An Exploratory Study
A1 Serrano-Castro, Pedro Jesús
A1 Ramírez-García, Teresa
A1 Cabezudo-García, Pablo
A1 García-Martín, Guillermina
A1 De-La-Parra, Juan
K1 Epilepsia
K1 Medicamentos - Interacciones
AB Most second and third generation antiseizure medications (ASMs) are associated with cognitive adverse events, which are a major concern for patients. However, the profile of cognitive adverse events differs between ASMs. This study investigated the effects of cenobamate on cognition in patients with drug-resistant epilepsy (DRE) within the Spanish Expanded Access Program (EAP).This was a retrospective, observational study. Inclusion criteria were age ≥ 18 years, DRE with focal seizures, and availability of cognition assessments and EAP authorization. Data were sourced from the clinical records of patients who took part in the Spanish cenobamate EAP. Primary endpoints included cognition (based on 20 neuropsychological outcomes, including verbal and visuospatial episodic memory, verbal fluency, executive function, working memory, attention, and speed of processing), seizure frequency, and concomitant antiseizure medication (ASM) usage at 6 months.
PB Springer Nature
YR 2024
FD 2024-01-24
LK https://hdl.handle.net/10630/29427
UL https://hdl.handle.net/10630/29427
LA spa
NO Serrano-Castro, P.J., Ramírez-García, T., Cabezudo-Garcia, P. et al. Effect of Cenobamate on Cognition in Patients with Drug-Resistant Epilepsy with Focal Onset Seizures: An Exploratory Study. CNS Drugs (2024). https://doi.org/10.1007/s40263-024-01063-6
NO Funding for open Access charge: Universidad de Málaga / CBUA.This study has been funded by Andalusian Network of Clinical and Translational Research in Neurology (Neuro-RECA) of the Ministry of Health and Consumer Affairs of Andalusia (code: RIC-0111-2019). Open access for this paper has been sponsored by the University of Malaga.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 24 ene 2026