RT Journal Article
T1 Carbon and oxygen minibeam radiation therapy: An experimental dosimetric evaluation
A1 Martínez Rovira, Immaculada
A1 González-Infantes, Wilfredo
A1 Brons, S.
A1 Prezado, Yolanda
K1 Radiobiología
K1 Hadrones
AB AbstractPurpose: To perform dosimetric characterization of a minibeam collimator in both carbon andoxygen ion beams to guide optimal set up geometry and irradiation for future radiobiological studiesusing these beams.Methods: Carbon and oxygen minibeams were generated using a prototype tungsten multislitcollimator presenting line apertures 700 μm wide, which are spaced 3500 μm centre-to-centredistance apart. Several radiation beam spots generated the desired field size of 15×15 mm2 andproduction of a 50 mm long spread out Bragg peak (SOBP) centered at 80 mm-depth in water. Doseevaluations were performed with two different detectors: a PTW microDiamond R© single crystaldiamond detector and radiochromic films (EBT3). Peak-to-valley dose ratio (PVDR) values, outputfactors (OF), penumbras and full width at half maximum (FWHM) were measured.Results: Measured lateral dose profiles exhibited spatial fractionation of dose at depth in a waterphantom in the expected form of peaks and valleys for both carbon and oxygen radiation fields.The diamond detector and radiochromic film provided measurements of PVDR in good agreement.PVDR values at shallow depth were about 60 and decreased to about 10 at 80 mm-depth in water.OF in the center of the SOBP was about 0.4; this value is larger than the corresponding one inproton minibeam radiation therapy measured using comparable collimator due to a reduced lateralscattering for carbon and oxygen minibeams.Conclusions: Carbon and oxygen minibeams may be produced by a mechanical collimator.PVDR values and output factors measured in this first study of these minibeam radiation typesindicate there is potential for their therapeutic use. Optimization of minibeam collimator designand the number and size of focal spots for irradiation are advocated to improve PDVR values anddose distributions for each specific applied use.
PB Wiley
YR 2017
FD 2017-05-29
LK https://hdl.handle.net/10630/36623
UL https://hdl.handle.net/10630/36623
LA eng
NO Martínez‐Rovira, I., González, W., Brons, S., & Prezado, Y. (2017). Carbon and oxygen minibeam radiation therapy: An experimental dosimetric evaluation. Medical Physics (Lancaster), 44(8), 4223–4229. https://doi.org/10.1002/mp.12383
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 21 ene 2026