RT Journal Article
T1 Hippocampal dentate gyrus coordínales brain-wide communication and memory updating through an inhibitory gating.
A1 Caramés-Tejedor, José María
A1 Pérez-Montoyo, Elena
A1 García-Hernández, Raquel
A1 Canals-Gamoneda, Santiago
K1 Hipocampo (Cerebro)
K1 Memoria
AB Distinct forms of memory processing are often causally identified with specific brain regions, but a key facet of memory processing includes linking separated neuronal populations. Using cell-specific manipulations of inhibitory neuronal activity, we discovered a key role of the dentate gyrus (DG) in coordinating dispersed neuronal populations during memory formation. In whole-brain fMRI and electrophysiological experiments, we found that parvalbumin (PV) interneurons in the DG control the functional coupling of the hippocampus within a wider network of neocortical and subcortical structures including the prefrontal cortex (PFC) and the nucleus accumbens (NAc). In a novel object-location task, regulation of PV interneuron activity enhanced or prevented memory encoding and, without effect upon the total number of task activated c-Fos+ cells, revealed a correlation between activated neuronal populations in the hippocampus-PFC-NAc network. These data suggest a critical regulatory role of PV interneurons in the dentate gyrus in brain-wide polysynaptic communication channels and the association of cell assemblies across multiple brain regions.
PB bioRxiv
YR 2020
FD 2020-07-14
LK https://hdl.handle.net/10630/33556
UL https://hdl.handle.net/10630/33556
LA eng
NO Caramés, J. M., Pérez-Montoyo, E., Garcia-Hernandez, R., & Canals, S. (2020). Hippocampal dentate gyrus coordinates brain-wide communication and memory updating through an inhibitory gating. BioRxiv, 2020.07.14.202218.
NO This work was supported by the Spanish State Research Agency through the Severo Ochoa Program for Centres of Excellence in R&D (SEV- 2017- 0723) and the Ministerio de Economía y Competitividad (MINECO) and FEDER funds under Grant No. BFU2015-64380-C2-1-R and PGC2018-101055-B-I00. J.M.C was supported by a FPU fellowship from the Ministerio de Educación of Spain (ref. 2012/1151); E.P-M was supported by a fellowship from the Consellería de Educación, Invetigación, Cultura y Deporte (ref. ACIF/2016/111).
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026