RT Journal Article
T1 Effects of the multiple sclerosis associated -330 promoter polymorphism in IL2 allelic expression
A1 Matesanz, Fuencisla
A1 Fedetz, María
A1 Leyva-Fernández, Laura
A1 Delgado, Concepción
A1 Alcina, Antonio
A1 Fernández-Fernández, Óscar
K1 Polimorfismo genético
K1 Esclerosis múltiple
AB The -330 IL2 gene promoter polymorphism has been associated with multiple sclerosis (MS) [J. Neuroimmunol. 119 (2001) 101], but the basis underlying this association remains unknown to date. In the present work, we have found that IL2 promoter-luciferase constructs, transfected in Jurkat cell line, showed twofold higher levels of gene expression in the -330 G allele. However, the transcriptional effect of this polymorphism in lymphocytes showed that the G allele was related to lower expression of IL2. This difference increased in the patient group. Divergence between in vivo and in vitro influence of the -330 IL2 promoter polymorphic site suggests the existence of additional unknown polymorphisms affecting gene regulation. Our data show an increased IL2 expression among GT and TT genotypes previously associated with susceptibility to MS.
PB Elsevier BV
YR 2004
FD 2004
LK https://hdl.handle.net/10630/33219
UL https://hdl.handle.net/10630/33219
LA eng
NO Fuencisla Matesanz, Maria Fedetz, Laura Leyva, Concepción Delgado, Oscar Fernández, Antonio Alcina, Effects of the multiple sclerosis associated −330 promoter polymorphism in IL2 allelic expression, Journal of Neuroimmunology, Volume 148, Issues 1–2, 2004, Pages 212-217, ISSN 0165-5728, https://doi.org/10.1016/j.jneuroim.2003.12.001.
NO This work was supported by grants PM 99/0101 from the MCYT and FIS PI020920 to A. Alcina, FIS 01/3149 to F. Matesanz, and FIS PI0210671 to L. Leyva. M. Fedetz is a holder of a fellowship from Hospital Carlos Haya Foundation.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 22 ene 2026