RT Journal Article
T1 Effects of 12-week aerobic exercise on patient-reported outcomes in women with systemic lupus erythematosus
A1 Gavilán-Carrera, Blanca
A1 Vargas-Hitos, José A
A1 Morillas-de-Laguno, Pablo
A1 Rosales-Castillo, Antonio
A1 Sola-Rodríguez, Sergio
A1 Callejas-Rubio, José L
A1 Sabio, José M
A1 Soriano-Maldonado, Alberto
K1 Lupus eritematoso
AB Purpose: To evaluate the effects of aerobic exercise on patient-reported outcomes (PROs) in women with systemic lupus erythematosus (SLE), and whether changes in cardiorespiratory fitness (CRF) mediate the changes in PROs.Methods: A total of 58 women with SLE were assigned to either an exercise group (EG; n = 26) or a control group (CG; n = 32) in this non-randomized clinical trial. The EG comprised 12 weeks of aerobic exercise (2 sessions/week) between 40%-75% of the individual's heart rate reserve. At baseline, and at week 12, CRF (Bruce test) and PROs were assessed including psychological stress (Perceived Stress Scale), sleep quality (Pittsburg Sleep Quality Index), fatigue (Multidimensional Fatigue Inventory), depressive symptoms (Beck Depression Inventory), and quality of life (36-item Short-Form Health Survey).Results: In comparison to the CG, the EG showed a significant reduction in general fatigue (mean difference (MD) -2.86 units; 95%CI -5.70 to -0.01; p = 0.049), physical fatigue (MD -4.33 units; 95%CI -7.02 to -1.65; p = 0.002) and a non-significant reduction of reduced motivation (MD - 1.29 units; 95%CI -2.60 to 0.03; p = 0.055). There were no significant between-group differences in the changes in psychological stress, sleep quality, depressive symptoms, quality of life, or other fatigue dimensions (all p > 0.05). Changes in CRF mediated the effects of the exercise intervention on general fatigue by 53.8%.Conclusion: The results suggest that 12 weeks of progressive aerobic exercise might improve relevant dimensions of fatigue in women with SLE, despite the absence of effects on other PROs. Improvements in CRF seem to mediate the effect of exercise on general fatigue.
PB Taylor & Francis Online
YR 2022
FD 2022-05
LK https://hdl.handle.net/10630/37093
UL https://hdl.handle.net/10630/37093
LA spa
NO Gavilán-Carrera B, Vargas-Hitos JA, Morillas-de-Laguno P, Rosales-Castillo A, Sola-Rodríguez S, Callejas-Rubio JL, Sabio JM, Soriano-Maldonado A. Effects of 12-week aerobic exercise on patient-reported outcomes in women with systemic lupus erythematosus. Disabil Rehabil. 2022 May;44(10):1863-1871
NO This work was supported by Fundación para la Investigación Biosanitaria de Andalucía Oriental (grantnumber: PI-0525-2016) and the Ilustre Colegio Oficial de Médicos de Granada (Premios de Investigación 2017).BG-C was supported by the Spanish Ministry of Education (FPU15/00002)
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 25 ene 2026