RT Journal Article T1 Medication and physical activity and physical fitness in severe mental illness. A1 Cuesta-Vargas, Antonio A1 Vera-Garcia, Elisa A1 Mayoral-Cleries, Fermin A1 Pérez-Cruzado, David Francisco K1 Ejercicio físico - Aspectos psicológicos AB Anti-psychotic medication has emerged as the primary medical treatment for people with severe mental illness, despite the great risks involved in the use of this medication. In addition, this population suffers from problems of obesity, sedentary lifestyle and poor physical fitness, which is aggravated by the use of this type of medication. The objective of this study is to explore the influence of the most commonly used antipsychotics in this population (Olanzapine and Risperidone) on physical activity and the physical fitness of people with severe mental illness. Sixty-two people between 26 and 61 years of age with severe mental illness were assessed. All participants were evaluated with a battery of 11 physical tests to assess their physical fitness and with the IPAQ-short version questionnaire to determine their level of physical activity. The doses of Risperidone and Olanzapine were also evaluated in all participants. Significant differences were found for physical activity, with higher levels reported in those patients with severe mental illness who did not take any of these medications. Regarding physical fitness, significant differences were only found for the consumption of Risperidone, with better physical fitness levels seen in patients who did not consume this medication; on the other hand, for the consumption of Olanzapine, differences were found in muscular strength, balance and aerobic condition with better values in non-Olanzapine consumers compared with Olanzapine consumers. PB Elsevier YR 2018 FD 2018 LK https://hdl.handle.net/10630/37777 UL https://hdl.handle.net/10630/37777 LA eng NO Perez-Cruzado D, Cuesta-Vargas A, Vera-Garcia E, Mayoral-Cleries F. Medication and physical activity and physical fitness in severe mental illness. Psychiatry Res. 2018 Sep;267:19-24. doi: 10.1016/j.psychres.2018.05.055. Epub 2018 May 23. PMID: 29879601. NO https://openpolicyfinder.jisc.ac.uk/id/publication/16060 NO This research was partially funded by grants from OTRI-UMA (ref 806/423505-1) with a part-time assistant research grant to David Perez-Cruzado. DS RIUMA. Repositorio Institucional de la Universidad de Málaga RD 22 ene 2026