RT Journal Article
T1 Adherence to the Mediterranean diet to prevent or delay hepatic steatosis: a longitudinal analysis within the PREDIMED study
A1 Cueto-Galán, Raquel
A1 Fontalba-Navas, Andrés
A1 Gutiérrez-Bedmar, Mario
A1 Ruiz-Canela, Miguel
A1 Martínez-González, Miguel A.
A1 Alves, Lilian
A1 Babio, Nancy
A1 Fitó, Montserrat
A1 Ros, Emilio
A1 Fiol, Miquel
A1 Estruch, Ramón
A1 Arós, Fernando
A1 Serra-Majem, Lluís
A1 Pintó, Xavier
A1 Muñoz-Bravo, Carlos
A1 García-Rodríguez, Antonio
A1 Gómez-Gracia, Enrique
K1 Hepatopatía grasa - Prevención
AB Little is known about the potential preventive efect of adherence to the Mediterranean diet (MedDiet) on the development of metabolic dysfunction-associated steatotic liver disease (MASLD).Aim: This study aims to determine the impact of adherence to the MedDiet on the progression of MASLD, measured using the hepatic steatosis index (HSI) at baseline and annually over a 5-year follow-up period within the framework of the PREvención con DIeta MEDiterránea (PREDIMED) study.Method: Participants from the PREDIMED trial with su cient available data (n = 3,145) were examined annually over 5 years. Adherence to the MedDiet was evaluated using the Mediterranean Diet Adherence Screener (MEDAS) questionnaire, and the presence/severity of hepatic steatosis was determined according to the HSI. Linear mixed models were used to analyze the association between the study variables and HSI.Results: The participants (57% female, 43% male) had a mean age of 67.2 (SD 6.2) years. Among the cardiovascular risk factors considered, the mean BMI was 29.81 (SD 3.62); 47% of participants had type 2 diabetes, 70% had hypercholesterolaemia, and 84% had hypertension. Over the 5-year follow-up, average adherence to the MedDiet and physical activity generally increased, while alcohol consumption, calorie intake, tobacco use, hypercholesterolaemia,and hypertension decreased. The fully adjusted multivariate model reflected a statistically significant decrease in the HSI per unit increase in adherence to theMedDiet (  = −0.075; 95% CI: −0.128, −0.021).Conclusion: In individuals at high cardiovascular risk, adherence to the MedDiet is significantly associated with improvements in HSI. These longitudinal findings highlight the important role of the MedDiet in delaying or slowing the natural progression of MASLD, contributing to both its prevention and clinicalmanagement.
PB Frontiers
YR 2025
FD 2025-05
LK https://hdl.handle.net/10630/44704
UL https://hdl.handle.net/10630/44704
LA eng
NO Cueto-Galán R, Fontalba-Navas A, Gutiérrez-Bedmar M, Ruiz-Canela M, Martínez-González MA, Alves L, Babio N, Fitó M, Ros E, Fiol M, Estruch R, Arós F, Serra-Majem L, Pintó X, Muñoz-Bravo C, García-Rodríguez A, Gómez-Gracia E. Adherence to the Mediterranean diet to prevent or delay hepatic steatosis: a longitudinal analysis within the PREDIMED study. Front Nutr. 2025 May 21;12:1518082. doi: 10.3389/fnut.2025.1518082. PMID: 40469667; PMCID: PMC12133482.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 3 mar 2026