RT Dissertation/Thesis
T1 Role of intestinal microbiota composition in colorectal cancer and in the response to neoadjuvant radiochemotherapy previous to surgery
A1 Sanchez Alcoholado, Lidia
K1 Cáncer colorrectal - Tesis doctorales
K1 Cáncer colorrectal - Tratamiento - Tesis doctorales
AB Intestinal-microbiota has been associated with different diseases, among which are obesity and colorectal cancer (CRC), microbiota is assumed to be a possible link between both disorders. Due to this, the composition of the fecal microbiota of patients with CRC with/without obesity was determined in comparison with the microbial profile of healthy-non-obese-controls, in order to unravel the possible relationship of the intestinal-microbiota with the state of inflammation, intestinal permeability, and a bacterial-derivated metabolite, TMAO, all in the context of obesity-associated CRC. Thus, the intestinal-microbiota of patients with CRC and obesity is characterized by the presence of greater abundance of opportunistic pathogens, which can alter the intestinal barrier function and can contribute to inflammatory processes related to CRC by increasing the production of inflammatory molecules (IL-1β, TMAO). On the other hand, gut-microbiota has been linked to the efficacy and toxicity of cancer treatments. Therefore, the identification of composition, abundance and diversity of the intestinal-microbiota that is associated with the response to preoperative-radiochemotherapy of patients with CRC (responders (R) and poor or non-responders (NR)) was determined, as well as the variations in concentrations of different bacterial-metabolites (polyamines, SCFAs). No significant changes were found in the diversity and composition of the intestinal-microbiota with exception of a significant decrease in Fusobacterium, Escherichia, Klebsiella and an increase in Bifidobacterium at post-treatment time compared to baseline.
PB UMA Editorial
YR 2022
FD 2022-01-25
LK https://hdl.handle.net/10630/23683
UL https://hdl.handle.net/10630/23683
LA eng
NO Also, a significant increase in the diversity and richness of R compared to NR was observed, with unfavorable pro-inflammatory bacterial taxa prevailing in the NR, and a significant increase in probiotics and butyrate-producing-bacteria in R. Furthermore, NR had significantly higher levels of some acetyl derivatives of polyamines and serum zonulin and significantly lower levels of fecal butyric acid than R. Suggesting that baseline intestinal composition in CRC patients is important in predicting the response of the gut microbiome to neoadyuvant radiochemotherapy.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 1 mar 2026