RT Journal Article
T1 Traditional Medicinal Plants as a Source of Inspiration for Osteosarcoma Therapy.
A1 Kazantseva, Liliya
A1 Becerra-Ratia, José
A1 Santos-Ruiz, Leonor
K1 Huesos - Cáncer
K1 Fitoterapia
K1 Plantas medicinales
AB Osteosarcoma is one of the most common types of bone cancers among paediatric patients. Despite the advances made in surgery, chemo-, and radiotherapy, the mortality rate of metastatic osteosarcoma remains unchangeably high. The standard drug combination used to treat this bone cancer has remained the same for the last 20 years, and it produces many dangerous side effects. Through history, from ancient to modern times, nature has been a remarkable source of chemical diversity, used to alleviate human disease. The application of modern scientific technology to the study of natural products has identified many specific molecules with anti-cancer properties. This review describes the latest discovered anti-cancer compounds extracted from traditional medicinal plants, with a focus on osteosarcoma research, and on their cellular and molecular mechanisms of action. The presented compounds have proven to kill osteosarcoma cells by interfering with different pathways: apoptosis induction, stimulation of autophagy, generation of reactive oxygen species, etc. This wide variety of cellular targets confer natural products the potential to be used as chemotherapeutic drugs, and also the ability to act as sensitizers in drug combination treatments. The major hindrance for these molecules is low bioavailability. A problem that may be solved by chemical modification or nano-encapsulation.
PB MDPI
SN 1420-3049
YR 2022
FD 2022-08-06
LK https://hdl.handle.net/10630/30529
UL https://hdl.handle.net/10630/30529
LA eng
NO Unión Europea - Horizon 2020, Marie Skłodowska-Curie (Grant agreement Nº 713721).Ministerio de Economía y Competitividad - MINECO (BIO2015–66266–R).Instituto de Salud Carlos III, RETICS, Red Española de Terapia Celular - TerCel (RD16/0011/0022).Instituto de Salud Carlos III, Consorcio Centro de Investigación Biomédica en Red-CIBER (CB06/06/1015).Consejería de Salud y Asuntos Sociales de la Junta de Andalucía (PI-0555-2013 y PI-0332-2016).Partial funding for open access charge: Universidad de Málaga / CBUA
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026