RT Journal Article T1 Is it possible to reduce pain-related fear in individuals with knee osteoarthritis? a systematic review of randomised clinical trials A1 Martinez Calderon, Javier A1 Flores Cortés, Mar A1 Morales-Asencio, José Miguel A1 Pineda-Galán, Consolación A1 García-Ríos, María Carmen A1 Torróntegui-Duarte, Marcelino A1 Luque-Suárez, Alejandro K1 Dolor K1 Rodilla AB ObjectiveTo evaluate the effectiveness of different interventions in reducing pain-related fear outcomes in people with knee osteoarthritis who have or have not had previous knee surgery, and to analyze whether included trials reported their interventions in full detail.MethodsSystematic searches were carried out in the Cochrane CENTRAL, CINAHL, EMBASE, PEDro, PsycINFO, PubMed, and SPORTDiscus from the inception of the database up to November 2019. Searches were manually updated to July 2021. We included randomized clinical trials that evaluated pain-related fear outcomes as a primary or secondary outcome in adults with knee osteoarthritis. The Cochrane Risk of Bias Tool 2 and the GRADE approach evaluated the risk of bias and the certainty of the evidence, respectively.ResultsEighteen trials were included. Four trials evaluated pain-related fear as a primary outcome and all evaluated kinesiophobia in samples that had previously undergone a knee surgical procedure. These trials found that interventions based primarily on cognitive aspects (e.g. cognitive-behavioral principles) can be effective in reducing kinesiophobia. Trials evaluating pain-related fear as the secondary outcome also found that interventions that included cognitive aspects (e.g. pain neuroscience education) decreased the levels of pain-related fear (e.g. fear of falling or kinesiophobia) in patients with or without a previous knee surgery. However, serious to very serious risk of bias and imprecisions were found in included trials. Thus, the certainty of the evidence was judged as low and very low using the GRADE approach. All trials reported insufficient details to allow a complete replication of their interventions.ConclusionsInterventions that include cognitive aspects may be the best option to reduce pain-related fear in people with knee osteoarthritis. However, we found a general low and very low certainty of the evidence and the findings should be considered with caution. PB Taylor and Francis Group YR 2022 FD 2022-06-07 LK https://hdl.handle.net/10630/34568 UL https://hdl.handle.net/10630/34568 LA eng NO Martínez-Calderón J., Flores-Cortes M., Morales-Asencio J.M., Pineda-Galán C., García-Ríos M.C., Torrontegui-Duarte M., & and Luque-Suarez A. (2023). Is it Possible to Reduce Pain-Related Fear in Individuals with Knee Osteoarthritis? a Systematic Review of Randomised Clinical Trials. Physiotherapy Theory and Practice, 39(6) 1106-1132. doi 10.1080/09593985.2022.2038743 DS RIUMA. Repositorio Institucional de la Universidad de Málaga RD 21 ene 2026