RT Journal Article T1 The underground life of homeodomain-leucine zipper transcription factors A1 Perotti, María Florencia A1 Arce, Agustín L. A1 Chan, Raquel Lía K1 Raíces (Botánica) K1 Factores de Transcripción AB Roots are the anchorage organs of plants, responsible for water and nutrient uptake, exhibiting high plasticity. Root architecture is driven by the interactions of biomolecules, including transcription factors and hormones that are crucial players regulating root plasticity. Multiple transcription factor families are involved in root development; some, such as ARFs and LBDs, have been well characterized, whereas others remain less well investigated. In this review, we synthesize the current knowledge about the involvement of the large family of homeodomain-leucine zipper (HD-Zip) transcription factors in root development. This family is divided into four subfamilies (I–IV), mainly according to structural features, such as additional motifs aside from HD-Zip, as well as their size, gene structure, and expression patterns. We explored and analyzed public databases and the scientific literature regarding HD-Zip transcription factors in Arabidopsis and other species. Most members of the four HD-Zip subfamilies are expressed in specific cell types and several individuals from each group have assigned functions in root development. Notably, a high proportion of the studied proteins are part of intricate regulation pathways involved in primary and lateral root growth and development. PB Oxford Academic YR 2021 FD 2021-03 LK https://hdl.handle.net/10630/44665 UL https://hdl.handle.net/10630/44665 LA eng NO María Florencia Perotti, Agustín Lucas Arce, Raquel Lía Chan, The underground life of homeodomain-leucine zipper transcription factors, Journal of Experimental Botany, Volume 72, Issue 11, 18 May 2021, Pages 4005–4021, https://doi.org/10.1093/jxb/erab112 NO https://openpolicyfinder.jisc.ac.uk/id/publication/1363 NO Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) NO Agencia Nacional de Promoción Científica y Tecnológica NO Universidad Nacional del Litoral NO PICT 2017 0305 NO PICT 2015 2671 DS RIUMA. Repositorio Institucional de la Universidad de Málaga RD 26 feb 2026