RT Journal Article
T1 Deletion of lysophosphatidic acid receptor LPA1 reduces neurogenesis in the mouse dentate gyrus
A1 Matas-Rico, Elisa
A1 Garcia Diaz, Beatriz
A1 Llebrez Zayas, Pedro
A1 López-Barroso, Diana
A1 Santín-Núñez, Luis Javier
A1 Pedraza-Benítez, María del Carmen
A1 Smith-Fernández, José Aníbal
A1 Téllez-Santana, Teresa
A1 Redondo-Bautista, Maximino
A1 Chun, Jerold
A1 Rodriguez-de-Fonseca, Fernando
A1 Estivill-Torrús, Guillermo
K1 Neurobiología del desarrollo
AB Neurogenesis persists in certain regions of the adult brain including the subgranular zone of the hippocampal dentate gyrus wherein its regulation is essential, particularly in relation to learning, stress and modulation of mood. Lysophosphatidic acid (LPA) is an extracellular signaling phospholipid with important neural regulatory properties mediated by specific G protein-coupled receptors, LPA1–5. LPA1 is highly expressed in the developing neurogenic ventricular zone wherein it is required for normal embryonic neurogenesis, and, by extension may play a role in adult neurogenesis as well. By means of the analyses of a variant of the original LPA1-null mutant mouse, termed the Malaga variant or “maLPA1-null,” which has recently been reported to have defective neurogenesis within the embryonic cerebral cortex, we report here a role for LPA1 in adult hippocampal neurogenesis. Proliferation, differentiation and survival of newly formed neurons are defective in the absence of LPA1 under normal conditions and following exposure to enriched environment and voluntary exercise. Furthermore, analysis of trophic factors in maLPA1-null mice demonstrated alterations in brain-derived neurotrophic factor and insulin growth factor 1 levels after enrichment and exercise. Morphological analyses of doublecortin positive cells revealed the anomalous prevalence of bipolar cells in the subgranular zone, supporting the operation of LPA1 signaling pathways in normal proliferation, maturation and differentiation of neuronal precursors.
PB Elsevier
YR 2008
FD 2008
LK https://hdl.handle.net/10630/32326
UL https://hdl.handle.net/10630/32326
LA eng
NO Elisa Matas-Rico, Beatriz García-Diaz, Pedro Llebrez-Zayas, Diana López-Barroso, Luis Santín, Carmen Pedraza, Anibal Smith-Fernández, Pedro Fernández-Llebrez, Teresa Tellez, Maximino Redondo, Jerold Chun, Fernando Rodríguez De Fonseca, Guillermo Estivill-Torrús, Deletion of lysophosphatidic acid receptor LPA1 reduces neurogenesis in the mouse dentate gyrus, Molecular and Cellular Neuroscience, Volume 39, Issue 3, 2008, Pages 342-355, ISSN 1044-7431, https://doi.org/10.1016/j.mcn.2008.07.014.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026