RT Journal Article
T1 Non-targeted metabolomics characterization of Annona muricata leaf extracts with anti-angiogenic activity
A1 Cárdenas García, Casimiro
A1 Torres-Vargas, José Antonio
A1 Cárdenas Valdivia, Abel
A1 Jurado, Nuria
A1 Rodríguez-Quesada, Ana María
A1 García-Caballero, Melissa
A1 Martínez-Póveda, Beatriz Amparo
A1 Medina-Torres, Miguel Ángel
K1 Neovascularización
AB The tropical plant Annona muricata has been widely used for traditional ethnobotanic and pharmacologic applications. Extracts from different parts of this plant have been shown to have a wide range of biological activities. In the present study, we carry out a metabolomic study of both aqueous and DMSO extracts from Annona muricata leaves that has allowed us to identify 33 bioactive compounds. Furthermore, we have shown that aqueous extracts are able to inhibit endothelial cell migration and both aqueous and DMSO extracts inhibit the formation of tubule-like structures by endothelial cells cultured on Matrigel. We conclude that extracts of Annona muricata leaves have great potential as anti-angiogenic natural combinations of bioactive compounds.
PB Elsevier
YR 2021
FD 2021-11
LK https://hdl.handle.net/10630/23975
UL https://hdl.handle.net/10630/23975
LA eng
NO Cárdenas, Casemiro ; Torres-Vargas, José Antonio ; Cárdenas Valdivia, Abel ; Jurado, Nuria ; Rodriguez-Quesada, Ana Maria ; García-Caballero, Melissa ; Martínez Poveda, Beatriz ; Medina Torres, Miguel Ángel. Non-targeted metabolomics characterization of Annona muricata leaf extracts with anti-angiogenic activity. Biomedicine & Pharmacotherapy Volume 144, December 2021, 112263. https://doi.org/10.1016/j.biopha.2021.112263
NO Funding for open access charge: Universidad de Málaga / CBUA. This work was supported by grants PID2019-105010RB-I00 (Spanish Ministry of Science, Innovation and Universities), UMA18-FEDERJA220, UMA18-FEDERJA-267 and PY20_00257 (Andalusian Government and FEDER) and funds from group BIO 267 (Andalusian Government). The “CIBER de Enfermedades Raras” and “CIBER de Enfermedades Vasculares” are initiatives from the ISCIII (Spain). The funders had no role in the study design, data collection and analysis, decision to publish or preparation of the manuscript.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026