RT Journal Article
T1 Profiling the Influence of Gene Variants Related to Folate-Mediated One-Carbon Metabolism on the Outcome of In Vitro Fertilization (IVF) with Donor Oocytes in Recipients Receiving Folic Acid Fortification
A1 Reyes Palomares, Arturo Lazaro
A1 Ruiz-Galdón, Maximiliano
A1 Liu, Kui
A1 Reyes-Engel, Armando
A1 Rodriguez-Wallberg, Kenny A.
K1 Embarazo
K1 Carbono
AB Nutritional status and gene polymorphisms of one-carbon metabolism confer a well-known interaction that in pregnant women may affect embryo viability and the health of the newborn. Folate metabolism directly impacts nucleotide synthesis and methylation, which is of increasing interest in the reproductive medicine field. Studies assessing the genetic influence of folate metabolism on IVF treatments have currently been performed in women using their own oocytes. Most of these patients seeking to have a child or undergoing IVF treatments are advised to preventively intake folate supplies that restore known metabolic imbalances, but the treatments could lead to the promotion of specific enzymes in specific women, depending on their genetic variance. In the present study, we assess the influence of candidate gene variants related to folate metabolism, such as Serine Hydroxymethyltransferase 1 SHMT1 (rs1979276 and rs1979277), Betaine-Homocysteine S-Methyltransferase BHMT (rs3733890), Methionine synthase reductase MTRR (rs1801394), Methylenetetrahydrofolate reductase MTHFR (rs1801131 and rs1801133), methionine synthase MTR (rs12749581), ATP Binding Cassette Subfamily B Member 1 ABCB1 (rs1045642) and folate receptor alpha FOLR1 (rs2071010) on the success of IVF treatment performed in women being recipients of donated oocytes. The implication of such gene variants seems to have no direct impact on pregnancy consecution after IVF; however, several gene variants could influence pregnancy loss events or pregnancy maintenance, as consequence of folic acid fortification.
PB IOAP-MPDI
YR 2022
FD 2022-09-25
LK https://hdl.handle.net/10630/25805
UL https://hdl.handle.net/10630/25805
LA eng
NO Palomares, A.R.; Ruiz-Galdon, M.; Liu, K.; Reyes-Engel, A.; Rodriguez-Wallberg, K.A. Profiling the Influence of Gene Variants Related to Folate-Mediated One-Carbon Metabolism on the Outcome of In Vitro Fertilization (IVF) with Donor Oocytes in Recipients Receiving Folic Acid Fortification. Int. J. Mol. Sci. 2022, 23, 11298. https://doi.org/10.3390/ijms231911298
NO Partial funding for open access charge: Universidad de Málaga
NO This research was funded by grant PTQ 09–01-00496, Ministerio de Economía y Competitividad (MINECO), Government of Spain, Instituto de Fertilidad Clínica Rincón y Fundación Rincón. AR Palomares and KA Rodriguez-Wallberg are supported by grants from the Swedish Research Council (VR Dnr 2021-06116, Dnr 2020–02230), the Swedish Cancer Society (CAN 2017/704, 20 0170 F) and Karolinska Institutet Research grants.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026