RT Journal Article
T1 Cellular identities in an unusual presentation of cyclopia in a chick embryo
A1 Palmquist-Gomes, Paul
A1 Pérez-Pomares, José María
A1 Guadix-Domínguez, Juan Antonio
K1 Ciclopia
K1 Gallinas - Embriones
AB Cyclopia is a congenital anomaly characterized by the presence of a single or partially divided eye in a single orbit at the body midline. This condition is usually associated with other severe facial malformations, such as the absence of the nose and, on rare occasions, the presence of a proboscis located above the ocular structures. The developmental origin of cyclopia in vertebrates is the failure of the embryonic prosencephalon to divide properly during the formation of the two bilateral eyes. Although the developmental origin of the cyclopia-associated proboscis is not clear, it has been suggested that this unique structure results from the disrupted morphogenesis of the olfactory placodes, the main organizers of the developing nose. In this study, we report a spontaneous congenital case of cyclopia with a proboscis-like appendage in a chick embryo. By means of both conventional histology and immunohistochemical methods, we have analyzed this anomaly in detail to suggest an alternative identity for the anatomical embryonic features of cyclopic vertebrate embryos displaying a proboscis. Our findings are discussed in the context of previously reported cases of cyclopia, and provide additional insight into this complex congenital malformation.
PB Wiley
YR 2019
FD 2019-07-12
LK https://hdl.handle.net/10630/45404
UL https://hdl.handle.net/10630/45404
LA eng
NO Palmquist-Gomes P, Pérez-Pomares JM, Guadix JA. Cellular identities in an unusual presentation of cyclopia in a chick embryo. J Exp Zool B Mol Dev Evol. 2019 Sep;332(6):179-186. doi: 10.1002/jez.b.22893. Epub 2019 Jul 12. PMID: 31298492.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 4 mar 2026