RT Journal Article
T1 A Partially Protective Vaccine for Fasciola hepatica Induced Degeneration of Adult Flukes Associated to a Severe Granulomatous Reaction in Sheep
A1 Molina-Hernández, Verónica
A1 Ruiz-Campillo, María Teresa
A1 Martínez-Moreno, Francisco Javier
A1 Buffoni, Leandro
A1 Martinez Moreno, Álvaro
A1 Zafra, Rafael
A1 Bautista, María José
A1 Escamilla-Sánchez, Alejandro
A1 Pérez-Caballero, Raúl
A1 Pérez, José
K1 Histología
AB Fasciolosis is a parasitic disease of livestock causing important economic losses worldwide and it is also a zoonosis. Current therapy relies on the use of anthelmintic drugs, which is no longer sustainable due to the increase of anthelmintic resistance and the risk of drug residues in food. A deep understanding of the host-parasite interaction is required to develop protective vaccines for the control of fasciolosis. The aim of the present study is to evaluate the hepatic lesions in sheep vaccinated with a partly protective vaccine for F. hepatica, a non-protective vaccine and an infected control group. The protective vaccine showed less severe hepatic lesions than the infected control group. In addition, in the protective vaccine group dead flukes surrounded by a severe granulomatous inflammation were observed, which taken together with the lower fluke burden, suggests that the host response induced by the partially protective vaccine may have been involved in the death of adult flukes of F. hepatica. This is the first study reporting the presence of degenerated flukes associated to a severe granulomatous inflammation in bile ducts in a vaccine trial, a finding that would be useful for improving vaccine efficacy in future trials.
PB MDPI
YR 2021
FD 2021-09-30
LK https://hdl.handle.net/10630/36153
UL https://hdl.handle.net/10630/36153
LA eng
NO Molina-Hernández, V.; Ruiz-Campillo, M.T.; Martínez-Moreno, F.J.; Buffoni, L.; Martínez-Moreno, Á.; Zafra, R.; Bautista, M.J.; Escamilla, A.; Pérez-Caballero, R.; Pérez, J. A Partially Protective Vaccine for Fasciola hepatica Induced Degeneration of Adult Flukes Associated to a Severe Granulomatous Reaction in Sheep. Animals 2021, 11, 2869. https://doi.org/10.3390/ani11102869
NO This research was funded by the EU grant H2020-SFS-2014-2-635408-PARAGONE and MINECO grant PID2019-108782RB-C21. VMH was supported by the “Juan de la Cierva-Incorporacion” contract (IJCI-2017-31366) of the Spanish Ministry of Science, Innovation and Universities.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026