RT Journal Article
T1 Identification of distinct ChAT+ neurons and activity-dependent control of postnatal SVZ neurogenesis.
A1 Páez-González, Patricia
A1 Asrican, Brent
A1 Rodriguez, Erica
A1 Kuo, Chay T.
K1 Neurobiología del desarrollo
AB Postnatal and adult subventricular zone (SVZ) neurogenesis is believed to be primarily controlled by neural stem cell (NSC)-intrinsic mechanisms, interacting with extracellular and niche-driven cues. Although behavioral experiments and disease states have suggested possibilities for higher level inputs, it is unknown whether neural activity patterns from discrete circuits can directly regulate SVZ neurogenesis. We identified a previously unknown population of choline acetyltransferase (ChAT)+ neurons residing in the rodent SVZ neurogenic niche. These neurons showed morphological and functional differences from neighboring striatal counterparts and released acetylcholine locally in an activity-dependent fashion. Optogenetic inhibition and stimulation of subependymal ChAT+ neurons in vivo indicated that they were necessary and sufficient to control neurogenic proliferation. Furthermore, whole-cell recordings and biochemical experiments revealed direct SVZ NSC responses to local acetylcholine release, synergizing with fibroblast growth factor receptor activation to increase neuroblast production. These results reveal an unknown gateway connecting SVZ neurogenesis to neuronal activity-dependent control and suggest possibilities for modulating neuroregenerative capacities in health and disease.
PB Springer Nature
YR 2014
FD 2014-06-01
LK https://hdl.handle.net/10630/40102
UL https://hdl.handle.net/10630/40102
LA eng
NO Paez-Gonzalez P, Asrican B, Rodriguez E, Kuo CT. Identification of distinct ChAT⁺ neurons and activity-dependent control of postnatal SVZ neurogenesis. Nat Neurosci. 2014 Jul;17(7):934-42. doi: 10.1038/nn.3734. Epub 2014 Jun 1. PMID: 24880216; PMCID: PMC4122286.
NO https://openpolicyfinder.jisc.ac.uk/id/publication/4008
NO National Institute of Health (USA)
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026