RT Conference Proceedings
T1 A plant virus causes symptoms through the deployment of a host-mimicking protein domain to attract the insect vector.
A1 Gao, Man
A1 Aguilar Parras, Emmanuel
A1 Garnelo-Gómez, Borja
A1 Medina-Puche, Laura
A1 Fan, Pengfei
A1 Ontiveros, Irene
A1 Pan, Shaojun
A1 Tan, Huang
A1 Von Roepenack-Lahaye, Edda
A1 Chen, Na
A1 Wang, Xiao-Wei
A1 Baulcombe, David C.
A1 Rodríguez-Bejarano, Eduardo
A1 Díaz-Pendón, Juan Antonio
A1 Furutani, Masahiko
A1 Morita, Miyo Terao
A1 Lozano-Durán, Rosa
K1 Virus fitopatógenos
AB During compatible plant-virus interactions, viruses can interfere with the normal developmental program of their hosts, leading to the appearance of phenotypes that we usually identify as ‘’symptoms of infection’’ (leaf curling and yellowing, stunting, dwarfism, necrosis). Despite their relevance, the molecular mechanisms underlying symptom induction and their biological meaning, if any, remain poorly understood. By using tomato yellow leaf curl virus (TYLCV, Geminivirus) as model, we have isolated C4 as the main protein responsible for the induction of TYLCV-associated symptoms in tomato. C4, by mimicking a host protein domain, the Conserved C-termini in LAZY1 protein family (CCL) domain, physically interacts with the RCC1-like domain-containing plant proteins (RLDs). By interacting with the RLDs through the CCL-like domain, C4 displaces one endogenous interactor, LAZY (LZY), interfering with RLD functions in processes such as auxin signaling and endomembrane trafficking, which correlates with the manifestation of symptoms. Surprisingly, we observed that appearance of C4-mediated symptoms in tomato plants plays no major role in viral replication nor movement, but they serve as attractants for the insect vector, the whitefly Bemisia tabaci, which preferentially feeds on tomato plants exhibiting strong symptoms of viral infection. These results suggest that, during plant-virus co-evolution, symptoms may have appeared as a strategy to promote viral transmission by the insect vector, at least in some specific plant-virus-vector pathosystems.
YR 2023
FD 2023
LK https://hdl.handle.net/10630/27049
UL https://hdl.handle.net/10630/27049
LA eng
NO Work in RLD’s lab is partially funded by the Excellence Strategy of the German Federal and State Governments, the ERC-COG GemOmics (101044142), the DeutscheForschungsgemeinschaft (DFG, German Research foundation) (project numbers LO 2314/1-1 and SBF 1101/3, C08), and a Royal Society Newton Advance grant (NA140481 – NAF\R2\180857). EA is the recipient of a Marie Skłodowska-Curie Grant from the European Union’s Horizon 2020 Research and Innovation Program (Grant 896910-GeminiDECODER).Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 3 mar 2026