RT Journal Article
T1 Modulating Vascular Lymphatic Growth in Disease: Current and Potential Pharmacological Approaches for Prevention and Treatment
A1 Martinez-Corral, Inés
A1 Trevaskis, Natalie L.
A1 García-Caballero, Melissa
K1 Sistema linfático - Enfermedades
AB The lymphatic system is part of the circulatory system and it is indispensable for life. In physiological conditions, the main functions assigned to the lymphatic system are the maintenance of the interstitial fluid homeostasis, immune surveillance and the absorption of dietary fat in the intestine (Alitalo, 2011). However, morphological or functional changes in lymphatic vessels can contribute to disorders such as lymphedema, tumor metastasis, inflammation and other pathological conditions (Oliver et al., 2020). Therefore, there is an urgent need to further understand the mechanisms driving lymphatic dysfunction in these conditions and to develop novel lymph-targeted therapies. In this Research Topic, we present a collection of research articles that provide new insights into obesity-induced lymphatic dysfunction and tumor-draining lymph node reconstruction; and review articles that highlight and discuss the latest pharmacological approaches to treat lymphedema and mechanisms to target obesity and metabolic diseases through modulating lymphatic contraction.
PB Frontiers Media
YR 2022
FD 2022-04-25
LK https://hdl.handle.net/10630/27104
UL https://hdl.handle.net/10630/27104
LA eng
NO Martinez-Corral I, Trevaskis NL and García-Caballero M (2022) Editorial: Modulating Vascular Lymphatic Growth in Disease: Current and Potential Pharmacological Approaches for Prevention and Treatment. Front. Pharmacol. 13:910142. doi: 10.3389/fphar.2022.910142
NO his study was supported by the Beatriz Galindo Programmefrom the Spanish Ministry of Education and ProfessionalFormation, Fundación Científica AECC(LABAE211691GARC) and the Instituto de Salud Carlos III(ISCIII) through the project “PI21/00653” and co-funded bythe European Union (MG-C).
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026