RT Journal Article
T1 Patient-attributable delay and its impact on two-year survival in breast cancer: A multicenter prospective cohort study
A1 Martin-García, Desirée
A1 García Aranda, Marilina
A1 Varela-Moreno, Esperanza
A1 Padilla- Ruiz, María
A1 Zarcos-Pedrinaci, Irene
A1 Rivas-Ruiz, Francisco
A1 Téllez-Santana, Teresa
A1 García-Gutiérrez, Susana
A1 González, Nerea
A1 Rivero, Amado
A1 Sarasqueta, Cristina
A1 Perestelo-Pérez, Lilisbeth
A1 Castells, Xavier
A1 Quintana, José María
A1 Sala, Maria
A1 Redondo-Bautista, Maximino
K1 Oncología
K1 Epidemiología
K1 Salud pública
K1 Educación sanitaria
K1 Mamas - Cáncer
AB BackgroundDelays in the diagnosis and treatment of breast cancer can be attributed to sociodemographic characteristics, clinical-pathological factors, and the functioning of the health system. This study aims to examine the impact of patient-attributable delay (PPAD) on timely medical care and its effect on patient survival.MethodsThis multicenter, prospective, observational study included 543 patients diagnosed with breast cancer between 2013 and 2015. A PPAD was defined as a delay of more than 90 days between symptom onset and consultation with a primary care physician or emergency department. The rate of PPAD in this population was 14.18 %.ResultsSegmented analysis revealed significant associations with age and living alone, with living alone emerging as the only independent predictor of PPAD (Odds Ratio OR: 1.882; 95 % Confidence Interval CI: 1.033–3.42). Significant associations were identified between clinical stage (p < 0.001), immunophenotype (p < 0.001), PPAD (p < 0.05), age (p < 0.001), household situation (p < 0.001) and body mass index (p < 0.05) with breast cancer prognosis. In the multivariate analysis, PPAD was an independent risk factor for two-year mortality (OR 3.08; 95 % CI 1.05–9.07), second only to clinical stage (OR 6.78; 95 % CI 2.51–18.3). Age also remained as a significant predictor (OR 1.04; 95 % CI 1.01–1.07).ConclusionOur findings highlight the need for targeted interventions to raise cancer symptom awareness and address barriers faced by vulnerable groups, such as the elderly and individuals living alone, to reduce delays, improve clinical outcomes, increase survival rates, and ultimately the quality of life for patients.
PB ELSEVIER
YR 2025
FD 2025-07
LK https://hdl.handle.net/10630/39265
UL https://hdl.handle.net/10630/39265
LA eng
NO Desirée Martín-García, Marilina García-Aranda, Esperanza Varela-Moreno, María Padilla-Ruiz, Irene Zarcos-Pedrinaci, Francisco Rivas-Ruiz, Teresa Téllez, Susana García-Gutiérrez, Nerea González, Amado Rivero, Cristina Sarasqueta, Lilisbeth Perestelo-Pérez, Xavier Castells, José María Quintana, María Sala, Maximino Redondo, Xavier Castells, Mercè Comas, Laia Domingo, Francesc Macià, Marta Roman, Anabel Romero, María Sala, Teresa Barata, Isabel Diez de la Lastra, Mariola de la Vega, Marisa Bare, Núria Torà, Joana Ferrer, Francesc Castanyer, Carmen Carmona, Susana García, Maximina Martín, Nerea González, Miren Orive, María Amparo Valverde, Alberto Saez, Inma Barredo, Manuel de Toro, Josefa Ferreiro, José María Quintana, Jeanette Pérez, Amado Rivero, Cristina Valcárcel, María Padilla, Maximino Redondo, Teresa Téllez, Irene Zarcos, Cristina Churruca, Amaia Perales, Javier Recio, Irune Ruiz, Cristina Sarasqueta, Jose María Urraca, Ma Jesús Michelena, Julio Moreno, Gaizka Mallabiabarrena, Patricia Cobos, Borja Otero, Javier Gorostiaga, Itsaso Troya, Patient-attributable delay and its impact on two-year survival in breast cancer: A multicenter prospective cohort study, European Journal of Surgical Oncology, Volume 51, Issue 8, 2025, 110280, ISSN 0748-7983, https://doi.org/10.1016/j.ejso.2025.110280. (https://www.sciencedirect.com/science/article/pii/S0748798325007085)
NO Funding for open access charge: Universidad de Málaga / CBUA
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 22 ene 2026