RT Journal Article
T1 Pattern of recurrence of early breast cancer is different according to intrinsic subtype and proliferation index.
A1 Ribelles, Nuria
A1 Jerez-Aragonés, José Manuel
A1 Pajares, Bella
A1 Vicioso-Recio, Luis Prudencio
A1 Jiménez-Rodríguez, Begoña
A1 De Luque, Vanessa
A1 Franco, Leónardo
A1 Gallego-Domínguez, Elena María
A1 Márquez, Antonia
A1 Álvarez, Martina
A1 Sánchez-Muñoz, Alfonso
A1 Pérez-Rivas, Luis G.
A1 Alba-Conejo, Emilio
A1 Ribelles, Nuria
K1 Mamas - Cáncer - Recidiva
K1 Marcadores tumorales
AB Recurrence risk in breast cancer varies throughout the follow-up time. We examined if these changesare related to the level of expression of the proliferation pathway and intrinsic subtypes.Results: Luminal A displayed a slow risk increase, reaching its maximum after three years and then remained steady.Luminal B presented most of its relapses during the first five years. HER2-enriched tumors show a peak of recurrencenearly twenty months post-surgery, with a greater risk in Ki-67 ≥14%. However a second peak occurred at 72 monthsbut the risk magnitude was greater in Ki-67 <14%. Triple negative tumors with low proliferation rate display a smoothrisk curve, but with Ki-67 ≥14% show sharp peak at nearly 18 months.Conclusions: Each intrinsic subtype has a particular pattern of relapses over time which change depending on thelevel of activation of the proliferation pathway assessed by Ki-67. These findings could have clinical implications bothon adjuvant treatment trial design and on the recommendations concerning the surveillance of patients.
PB BMC
YR 2013
FD 2013-10-22
LK https://hdl.handle.net/10630/31184
UL https://hdl.handle.net/10630/31184
LA eng
NO Ribelles N, Perez-Villa L, Jerez JM, Pajares B, Vicioso L, Jimenez B, de Luque V, Franco L, Gallego E, Marquez A, Alvarez M, Sanchez-Muñoz A, Perez-Rivas L, Alba E. Pattern of recurrence of early breast cancer is different according to intrinsic subtype and proliferation index. Breast Cancer Res. 2013;15(5):R98. doi: 10.1186/bcr3559. PMID: 24148581; PMCID: PMC3978680.
NO Articulo publicado en la revista Breast Cancer Research.Esta versión tiene Licencia Creative Commons CC-BYSÍ permite usos comerciales y SÍ permite obras derivadas
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026