RT Journal Article
T1 Assessment of hormone-like activities in Ginkgo biloba, Elettaria cardamomum and Plantago ovata extracts using in vitro receptor-specific bioassays
A1 Real-Domínguez, María Macarena
A1 Molina-Molina, José-Manuel
A1 Jimenez, Jesús
A1 Diéguez, Horacio R.
A1 Fernández, Mariana
A1 Olea, Nicolás
K1 Plantas medicinales
K1 Andrógenos
K1 Ensayos biológicos
AB Medicinal plants are widely used for the treatment of diseases and for the development of new drugs. This study was designed to determine the presence of hormone-like activities dependent on the activation of human estrogen receptor alpha (hERa) and/or androgen receptor (hAR) in methanol extracts prepared from three medicinal plants historically and currently used for therapeutic purposes: Ginkgo biloba leaves (GBL), Elettaria cardamomum seeds (ECS) and Plantago ovata seeds (POS). After a solid-liquid extraction (SLE) step, their effects on hERa function were assessed in MCF-7 breast cancer cells using the E-Screen bioassay, and their ability to induce hAR-mediated reporter gene expression was evaluated using the androgen-sensitive stable prostatic PALM cell line. Unlike POS extracts, GBL and ECS extracts showed estrogenic (0.07 and 0.20 nM E2Eq mg(-1), respectively) and anti-estrogenic (0.01 and 0.02 μM ICI182780Eq mg(-1), respectively) activities. ECS extracts evidenced androgenic activity (0.30 nM R1881Eq mg(-1)) and POS extracts anti-androgenic activity (22.30 μM ProcEq mg(-1)). According to these findings, these plant extracts may interfere with the endocrine system via one or more hormonal receptors, and further investigation is warranted into their role as endocrine disrupters in humans
PB Taylor & Francis
YR 2015
FD 2015
LK https://hdl.handle.net/10630/34100
UL https://hdl.handle.net/10630/34100
LA eng
NO Real M, Molina-Molina JM, Jimenez J, Diéguez HR, Fernández MF, Olea N. Assessment of hormone-like activities in Ginkgo biloba, Elettaria cardamomum and Plantago ovata extracts using in vitro receptor-specific bioassays. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2015;32(9):1531-41. doi: 10.1080/19440049.2015.1071922. Epub 2015 Aug 4. PMID: 26161806.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 24 ene 2026