RT Journal Article
T1 Expression of the Antiapoptotic Proteins Clusterin and Bcl-2 in Laryngeal Squamous Cell Carcinomas
A1 Redondo-Bautista, Maximino
A1 Esteban, Francisco
A1 González-Moles, Miguel A.
A1 Delgado-Rodríguez, Miguel
A1 Nevado, Manuel
A1 Torres-Muñoz, Jorge E.
A1 Téllez-Santana, Teresa
A1 Villar, Eduardo
A1 Morell Ocaña, Miguel
A1 Petito, Carol K.
K1 Glucoproteínas
K1 Laringe - Cáncer
AB Bcl-2 and clusterin genes have been related to the inhibition of apoptosis, an event that plays a key role in malignant transformation and in invasive disease. In this work, we determine the significance of clusterin and bcl-2 expression in a large series of laryngeal carcinomas. We used immunohistochemical methods and in situ hybridization to examine the expression of these proteins. Nontumoral epithelial laryngeal tissues did not express clusterin and bcl-2 proteins. However, 9% (14 out of 154) and 25% of these tumors (39 of 154) had positive clusterin and bcl-2 staining, respectively. Clusterin expression was significantly related to the degree of local invasion and higher bcl-2 expression was found in these clusterin-positive tumors (p < 0.05). Bcl-2 expression was significantly correlated with supraglottic localization, nodal metastases, invasion in depth, and poorly differentiated tumors. However, by multivariate analysis, bcl-2 was shown to be an independent predictor of good prognosis in these tumors (OR = 0.12, 95% CI = 0.02-0.91). These findings indicate that clusterin and bcl-2 are upregulated in laryngeal carcinomas and their expression is related to the invasiveness of these tumors.
PB Karger
YR 2006
FD 2006
LK https://hdl.handle.net/10630/36808
UL https://hdl.handle.net/10630/36808
LA eng
NO Redondo M, Esteban F, González-Moles MA, Delgado-Rodríguez M, Nevado M, Torres-Muñoz JE, Tellez T, Villar E, Morell M, Petito CK. Expression of the antiapoptotic proteins clusterin and bcl-2 in laryngeal squamous cell carcinomas. Tumour Biol. 2006;27(4):195-200. doi: 10.1159/000093055. Epub 2006 May 2. PMID: 16675913.
NO https://openpolicyfinder.jisc.ac.uk/id/publication/13040
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 22 ene 2026