RT Journal Article
T1 Dopamine D2 and D4 receptor heteromerization and its allosteric receptor-receptor interactions
A1 Borroto-Escuela, Dasiel O.
A1 Craenenbroeck, Kathleen Van
A1 Romero-Fernandez, Wilber
A1 Guidolin, Diego
A1 Woods, Amina S.
A1 Rivera, Alicia
A1 Haegeman, Guy
A1 Agnati, Luigi F.
A1 Tarakanov, Alexander O.
A1 Fuxe, Kjell
K1 Receptores
K1 Dopamina - Receptores
AB Dopamine D2 and D4 receptors partially codistribute in the dorsal striatum and appear to play a fundamental role in complex behaviors and motor function. The discovery of D2R-D4.xR (D4.2R, D4.4R or D4.7R) heteromers has been made in cellular models using co-immunoprecipitation, in situ Proximity Ligation Assays and BRET1 techniques with the D2R and D4.7R receptors being the least effective in forming heteromers. Allosteric receptor-receptor interactions in D2R-D4.2R and D2R-D4.4 R heteromers were observed using the MAPK assays indicating the existence of an enhancing allosteric receptor-receptor interaction in the corresponding heteromers between the two orthosteric binding sites. The bioinformatic predictions suggest the existence of a basic set of common triplets (ALQ and LRA) in the two participating receptors that may contribute to the receptor-receptor interaction interfaces.
PB Elsevier
SN 1090-2104
YR 2011
FD 2011-01-28
LK https://hdl.handle.net/10630/45029
UL https://hdl.handle.net/10630/45029
LA eng
NO Dasiel O. Borroto-Escuela, Kathleen Van Craenenbroeck, Wilber Romero-Fernandez, Diego Guidolin, Amina S. Woods, Alicia Rivera, Guy Haegeman, Luigi F. Agnati, Alexander O. Tarakanov, Kjell Fuxe, Dopamine D2 and D4 receptor heteromerization and its allosteric receptor–receptor interactions, Biochemical and Biophysical Research Communications, Volume 404, Issue 4, 2011, Pages 928-934, ISSN 0006-291X, https://doi.org/10.1016/j.bbrc.2010.12.083.
NO Swedish Research Council (Vetenskapsrådet)
NO Torsten and Ragnar Söderberg
NO M.M. Wallenberg Foundation
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 3 mar 2026