RT Journal Article
T1 The Relationship between Depressive Symptoms, Quality of Life and miRNAs 8 Years after Bariatric Surgery.
A1 Mela, Virginia
A1 Agüera, Zaida
A1 Álvarez Bermúdez, María Dolores
A1 Martín-Reyes, Flores
A1 Granero, Roser
A1 Sánchez-García, Ana
A1 Oliva-Olivera, Wilfredo
A1 Tomé, Monica
A1 Moreno-Ruiz, Francisco Javier
A1 Soler Humanes, Rocio
A1 Fernández-Serrano, José Luis
A1 Sánchez-Gallegos, María Pilar
A1 Martínez-Moreno, José Manuel
A1 Sancho-Marín, Raquel
A1 Fernández-Aranda, Fernando
A1 García-Fuentes, Eduardo
A1 Tinahones-Madueño, Francisco José
A1 Garrido-Sánchez, Lourdes
K1 Obesidad
K1 Depresión mental
K1 Acido ribonucleico
K1 Calidad de vida
K1 Cirugía
AB Background: There are conflicting results on whether weight loss after bariatric surgery (BS) might be associated with quality of life (QoL)/depressive symptomatology. We aim to deter- mine whether BS outcomes are associated with QoL/depressive symptomatology in studied pa- tients at the 8-year follow-up after BS, as well as their relationship with different serum proteins and miRNAs. (2) Methods: A total of 53 patients with class III obesity who underwent BS, and then classified into “good responders” and “non-responders” depending on the percentage of excess weight lost (%EWL) 8 years after BS (%EWL ≥ 50% and %EWL < 50%, respectively), were included.Basal serum miRNAs and different proteins were analysed, and patients completed tests to evaluate QoL/depressive symptomatology at 8 years after BS. (3) Results: The good responders group showed higher scores on SF-36 scales of physical functioning, role functioning—physical, role func- tioning—emotional, body pain and global general health compared with the non-responders. The expression of hsa-miR-101-3p, hsa-miR-15a-5p, hsa-miR-29c-3p, hsa-miR-144-3p and hsa-miR-19b- 3p were lower in non-responders. Hsa-miR-19b-3p was the variable associated with the response to BS in a logistic regression model. (4) Conclusions: The mental health of patients after BS is limited by the success of the intervention. In addition, the expression of basal serum miRNAs related to depression/anxiety could predict the success of BS.
PB MDPI
YR 2023
FD 2023-09-22
LK https://hdl.handle.net/10630/36408
UL https://hdl.handle.net/10630/36408
LA eng
NO Mela, V.; Agüera, Z.; Alvarez-Bermudez, M.D.; Martín-Reyes, F.; Granero, R.; Sánchez-García, A.; Oliva-Olivera, W.; Tomé, M.; Moreno-Ruiz, F.J.; Soler-Humanes, R.; et al. The Relationship between Depressive Symptoms, Quality of Life and miRNAs 8 Years after Bariatric Surgery. Nutrients 2023, 15, 4109. hps://doi.org/10.3390/nu15194109
NO OA Publishing: This option includes Open Access publishingEmbargo: No embargoLicence: CC BY 4.0Copyright Owner: AuthorsPublisher Deposits: PubMed CentralLocations: Any Website. Named Repository (PubMed Central). Journal WebsiteConditions  Published source must be acknowledged with citationNotes: Authors are encouraged to submit their published articles to institutional repositories
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026