RT Journal Article
T1 Organ-specific allergen challenges in airway allergy: Current  utilities and future directions
A1 Fauquert, J. L.
A1 Alba-Linero, Carmen
A1 Gherasim, A.
A1 Testera Montes, A.
A1 Bentabol-Ramos, G.
A1 Saenz de Santa María-García, Rocío
A1 Torres-Jaén, María Josefa
A1 Eguiluz-Gracia, Ibón
A1 Rondon, C.
K1 Alergia-Diagnóstico
K1 Alergia-Tratamiento
AB Atopy has been long used as the screening method for airway allergy. Nevertheless, aeroallergens can trigger respiratory symptoms not only in atopic patients (atopic res piratory allergy, ARA), but also in non-atopic subjects (local respiratory allergy, LRA). Moreover, ARA and LRA can coexist in the same patient, and this clinical scenario has been called dual respiratory allergy (DRA). When the clinical history cannot determine the relevance of sensitizations in ARA patients, nasal, conjunctival or bronchial aller gen challenges (NAC, CAC, and BAC, respectively) should be conducted. Moreover, these tests are required to identify patients with LRA and DRA. The clarification of the allergic triggers of airway diseases has a profound impact on the management strategies the patients can be offered. Importantly, allergen immunotherapy (AIT) remains as the only disease-modifying intervention for ARA. Recent data indicate that AIT might have a similar effect on LRA patients. Nevertheless, AIT success relies largely on the correct phenotyping of allergic individuals, and NAC, CAC, and BAC are very helpful tools in this regard. In this review, we will summarize the main indications and methodology of CAC, NAC, and BAC. Importantly, the clinical implementation of these tests might translate into precision medicine approaches and better health outcomes for patients with airway allergy.
PB Wiley
YR 2023
FD 2023
LK https://hdl.handle.net/10630/26347
UL https://hdl.handle.net/10630/26347
LA eng
NO Fauquert JL, Alba-Linero C, Gherasim A, Testera-Montes A, Bentabol-Ramos G, Saenz de Santa Maria-Garcia R, Torres MJ, Eguiluz-Gracia I, Rondon C. Organ-specific allergen challenges in airway allergy: Current utilities and future directions. Allergy. 2023 Apr 1. doi: 10.1111/all.15731. Epub ahead of print. PMID: 37002709.
NO Consejería de Salud, Junta de Andalucía, Grant/Award Number: P20_00405; Instituto de Salud Carlos III, Grant/Award Number: PI20/01715, RD21/0002/0008, CM21/00262, CM20/00160, JR22/00048 and JR19/00029.Funding for open access charge: Universidad de Málaga / CBUA.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026