RT Journal Article
T1 Thigh and abdominal adipose tissue depot associations with testosterone levels in postmenopausal females
A1 Ofori, Emmanuel K.
A1 Conde Alonso, Sonia
A1 Correas-Gómez, Lorena
A1 Álvarez-Carnero, Elvis
A1 Zwygart, Karin
A1 Hugues, Henry
A1 Bardy, Daniel
A1 Hans, Didier
A1 Dwyer, Andrew A.
A1 Amati, Francesca
K1 Tejido adiposo
K1 Cuerpo humano - Composición
AB Objective. Research findings on the relationship between serum androgens and adipose tissue in older females are inconsistent. We aimed to clarify the relationship using state-of-the-art techniques to evaluate associations between body fat distribution and plasma testosterone (T) levels in older postmenopausal women.Design. Observational, cross-sectional study of healthy, community dwelling postmenopausal women.Patients and Measurements. Postmenopausal women (60-80 years old) were included in this study. Overall body composition was evaluated by dual-energy X-ray absorptiometry. Abdominal and thigh fat depots were measured by magnetic resonance imaging. Circulating T concentrations were analysed by liquid chromatography-tandem mass spectrometry.Results. Thirty-five women (66.6 ± 0.8 years) participated in this study. T levels were positively associated with clinical proxy measures of adiposity including weight (ρ = 0.39), BMI (ρ = 0.43) and waist circumference (ρ = 0.39) (all P < 0.05). Fat mass and % body fat were correlated with T levels (ρ = 0.42 and 0.38 respectively, both P < 0.05). T correlated with overall and superficial abdominal fat (ρ = 0.34 and 0.37 respectively, both P < 0.05) but not with visceral adipose tissue. T increased with greater thigh fat (ρ = 0.49, P < 0.05) in both superficial and deep depots (ρ = 0.50 and 0.35 respectively, both P < 0.05).Conclusion. Our results suggest that postmenopausal women with higher circulating T levels have both higher regional and overall body adiposity. These findings underscore the sexual dimorphism in the relationship between serum androgen levels and adiposity.
PB WILEY
YR 2019
FD 2019
LK https://hdl.handle.net/10630/45894
UL https://hdl.handle.net/10630/45894
LA eng
NO Ofori EK, Conde Alonso S, Correas‐Gomez L, et al. Thigh and abdominal adipose tissue depotassociations with testosterone levels in postmenopausalfemales. Clin Endocrinol. 2019;90:433–439. https://doi.org/10.1111/cen.13921
NO Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
NO Grant/Award Number: PZ003_126339, PZ00P3_149398 and 320030_170062
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 17 mar 2026