RT Journal Article
T1 Influence of depression on survival of colorectal cancer patients drawn from a large prospective cohort
A1 Varela-Moreno, Esperanza
A1 Rivas-Ruiz, Francisco
A1 Padilla Ruiz, María del Carmen
A1 Alcaide-García, Julia
A1 Zarcos-Pedrinaci, Irene
A1 Téllez-Santana, Teresa
A1 Fernández-de Larrea-Baz, Nerea
A1 Baré, Marisa
A1 Bilbao, Amaia
A1 Sarasqueta, Cristina
A1 Morales-Suárez-Varela, María Manuela
A1 Aguirre, Urko
A1 Quintana, José María
A1 Redondo-Bautista, Maximino
K1 Oncología - Aspectos psicológicos
AB ObjectiveThe prevalence of depressive symptoms immediately after the diagnosis of colorectal cancer (CRC) is high and has important implications both psychologically and on the course of the disease. The aim of this study is to analyse the association between depressive symptoms and CRC survival at 5 years after diagnosis.MethodsThis multicentre, prospective, observational cohort study was conducted on a sample of 2602 patients with CRC who completed the Hospital Anxiety and Depression Scale (HADS-D) at 5 years of follow-up. Survival was analysed using the Kaplan–Meier method and Cox regression models.ResultsAccording to our analysis, the prevalence of depressive symptoms after a CRC diagnosis was 23.8%. The Cox regression analysis identified depression as an independent risk factor for survival (HR = 1.47; 95% CI: 1.21–1.8), a finding which persisted after adjusting for sex (female: HR = 0.63; 95% CI: 0.51–0.76), age (>70 years: HR = 3.78; 95% CI: 1.94–7.36), need for help (yes: HR = 1.43; 95% CI: 1.17–1.74), provision of social assistance (yes: HR = 1.46; 95% CI: 1.16–1.82), tumour size (T3–T4: HR = 1.56; 95% CI: 1.22–1.99), nodule staging (N1–N2: HR = 2.46; 95% CI: 2.04–2.96), and diagnosis during a screening test (yes: HR = 0.71; 95% CI: 0.55–0.91).ConclusionsThere is a high prevalence of depressive symptoms in patients diagnosed with CRC. These symptoms were negatively associated with the survival rate independently of other clinical variables. Therefore, patients diagnosed with CRC should be screened for depressive symptoms to ensure appropriate treatment can be provided.
PB Wiley
YR 2022
FD 2022-08-21
LK https://hdl.handle.net/10630/28624
UL https://hdl.handle.net/10630/28624
LA eng
NO Varela‐MorenoE,Rivas‐RuizF,Padilla‐RuizM,etal.Influenceofdepressiononsurvivalofcolorectalcancerpatientsdrawnfromalargeprospectivecohort.Psychooncology.2022;31(10):1762‐1773.https://doi.org/10.1002/pon.6018
NO Funding for open Access charge: Universidad de Málaga / CBUA.This study was supported by public grant from Instituto de Salud Carlos III (PI09/90397, PS09/00314, PS09/00746, PI09/90460, PI/0990490, PI13/01692, PI13/00013, PI18/01181, Pi18/01589) and was co-funded by the European Regional Development fund.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 22 ene 2026