RT Journal Article
T1 Dirigent proteins in plants: modulating cell wall metabolism during abiotic and biotic stress exposure
A1 Paniagua, Candelas
A1 Bilkova, Anna
A1 Jackson, Phil
A1 Dabravolski, Siarhei
A1 Riber, Willi
A1 Didi, Vojtech
A1 Houser, Josef
A1 Gigli-Bisceglia, Nora
A1 Wimmerova, Michaela
A1 Budínská, Eva
A1 Hamann, Thorsten
A1 Hejatko, Jan
K1 Paredes celulares vegetales
K1 Plantas
K1 Biosíntesis
AB Dirigent (DIR) proteins were found to mediate regio- and stereoselectivity of bimolecular phenoxy radical couplingduring lignan biosynthesis. Here we summarize the current knowledge of the importance of DIR proteins in lignan andlignin biosynthesis and highlight their possible importance in plant development. We focus on the still rather enigmaticArabidopsis DIR gene family, discussing the few members with known functional importance. We comment on recentdiscoveries describing the detailed structure of two DIR proteins with implications in the mechanism of DIR-mediatedcatalysis. Further, we summarize the ample evidence for stress-induced dirigent gene expression, suggesting the roleof DIRs in adaptive responses. In the second part of our work, we present a preliminary bioinformatics-based charac-terization of the AtDIR family. The phylogenetic analysis of AtDIRs complemented by comparison with DIR proteins ofmostly known function from other species allowed us to suggest possible roles for several members of this family andidentify interesting AtDIR targets for further study. Finally, based on the available metadata and our in silico analysis ofAtDIR promoters, we hypothesize about the existence of specific transcriptional controls for individual AtDIR genesand implicate them in various stress responses, hormonal regulations, and developmental processes.
PB Oxford University Press
YR 2017
FD 2017
LK https://hdl.handle.net/10630/33425
UL https://hdl.handle.net/10630/33425
LA eng
NO Dirigent proteins in plants: modulating cell wall metabolism during abiotic and biotic stress exposure, Journal of Experimental Botany, Volume 68, Issue 13, 22 August 2017, Pages 3287–3301,
NO Este artículo revisa el papel de las proteínas Dirigent (DIR) en la biosíntesis de lignanos y lignina, y su posible importancia en el desarrollo de las plantas. Destaca estudios sobre la familia de genes DIR en *Arabidopsis*, que aún es poco comprendida, y analiza la estructura de algunas proteínas DIR con implicaciones en su mecanismo catalítico. También se discute la evidencia que relaciona la expresión de genes DIR con respuestas al estrés, sugiriendo que estas proteínas pueden tener un papel en la adaptación de las plantas. Además, se presenta un análisis filogenético de los genes *AtDIR*, proponiendo funciones potenciales para varios miembros y su posible control transcripcional en respuestas al estrés y procesos de desarrollo.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026