RT Journal Article
T1 Synthesis of (-)-cannabidiol (CBD),(-)-Δ9- and(-)--Δ8-tetrahydrocannabinols, encapsulation of CBD with nanoparticles for controlled delivery and biological evaluation
A1 Moya-Utrera, Federico
A1 Fuentes-Ríos, David
A1 Romero-Carrasco, Antonio
A1 Doña Flores, Manuel
A1 Cheng-Sánchez, Iván
A1 Díaz-Morilla, Amelia
A1 Pino-González, María Soledad
A1 Martínez-Férez, Antonio
A1 Moreno, Javier
A1 Mesas, Cristina
A1 Melguizo, Consolación
A1 Prados, José
A1 Sarabia-García, Francisco Ramón
A1 López-Romero, Juan Manuel
K1 Cannabinoides - Síntesis
AB Cannabidiol (CBD) is garnering increasing interest due to its significant biological activity. This natural compound is one of the major cannabinoids in Cannabis sativa L. In this work, we describe the encapsulation of CBD in solid and hollow pH-sensitive poly(4-vinylpyridine) (solid@p4VP and hollow@p4VP) nanoparticles, and temperature-sensitive poly(N-isopropylacrylamide) (solid@pNIPAM and hollow@pNIPAM) nanoparticles for transport and release CBD in a controlled manner. The CBD loading into these smart polymeric systems was effective and their release profiles, solubility and resistance to stomach and intestinal conditions were evaluated, showing satisfactory properties and improved bioavailability with respect to free CBD. Finally, the A549 human lung cancer cell line was used as lung adenocarcinoma epithelial cellular model to carry out preliminary assays of the in vitro activity of the vehiculized CBD. For all these studies, synthetic CBD was employed, for which a new efficient and scalable synthesis of cannabinoids has been developed.
PB Wiley
YR 2024
FD 2024-12
LK https://hdl.handle.net/10630/36054
UL https://hdl.handle.net/10630/36054
LA eng
NO F. Moya-Utrera, D. Fuentes-Ríos, A. Romero-Carrasco, M. Doña-Flores, I. Cheng-Sánchez, A. Díaz-Morilla, M. Soledad Pino-González, A. Martínez-Ferez, J. Moreno, C. Mesas, C. Melguizo, J. Prados, F. Sarabia, J. M. López-Romero, Chem. Eur. J. 2024, 30, e202402496. https://doi.org/10.1002/chem.202402496
NO This work was financially supported by the Ministerio deCiencias e Innovación (MICINN) (ref. RTI2018–098296-BI00),Junta de Andalucía (FQM397), “Fondo Europeo de DesarrolloRegional-FEDER” (UMA20 FEDERJA84) and Salud & Semillas(Contract 8.06/5.81.5984). F. M.-U. thanks Salud & Semillas andJunta de Andalucía for predoctoral fellowships (Ref. [8].06/5.81.5984 and FQM158) The authors thank the Mass Spectrom-etry and NMR facilities of the University of Málaga for exactmass and NMR spectroscopic assistances, respectively. They alsothank Dr. Olivier Blacque from the University of Zurich for theX-ray diffraction analysis of CBD.Funding for open access  charge: Universidad de  Málaga / CBUA
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 4 mar 2026