RT Journal Article
T1 Calcium Homeostasis in the Development of Resistant Breast Tumors.
A1 Martin-García, Desirée
A1 Téllez-Santana, Teresa
A1 Redondo-Bautista, Maximino
A1 García Aranda, Marilina
K1 Mamas - Cáncer
K1 Calcio - Uso terapéutico - Ensayos
AB Cancer is one of the main health problems worldwide. Only in 2020, this disease caused more than 19 million new cases and almost 10 million deaths, with breast cancer being the most diagnosed worldwide. Today, despite recent advances in breast cancer treatment, a significant percentage of patients will either not respond to therapy or will eventually experience lethal progressive disease. Recent studies highlighted the involvement of calcium in the proliferation or evasion of apoptosis in breast carcinoma cells. In this review, we provide an overview of intracellular calcium signaling and breast cancer biology. We also discuss the existing knowledge on how altered calcium homeostasis is implicated in breast cancer development, highlighting the potential utility of Ca2+ as a predictive and prognostic biomarker, as well as its potential for the development of new pharmacological treatments to treat the disease.
PB MDPI
YR 2023
FD 2023-05-23
LK https://hdl.handle.net/10630/27135
UL https://hdl.handle.net/10630/27135
LA eng
NO Martin-García D, Téllez T, Redondo M, García-Aranda M. Calcium Homeostasis in the Development of Resistant Breast Tumors. Cancers. 2023; 15(11):2872. https://doi.org/10.3390/cancers15112872
NO Partial funding for open access charge: Universidad de Málaga.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 22 ene 2026