RT Conference Proceedings T1 Selected problems/cases to stimulate collaborative learning regarding the dynamic flexibility of metabolism. A1 Medina-Torres, Miguel Ángel A1 Suárez-Marín, María Fernanda A1 Alonso-Carrión, Francisco José K1 Metabolismo - Estudio y enseñanza superior - Innovaciones K1 Bioquímica - Estudio y enseñanza superior - Innovaciones AB Metabolic reprogramming has been identified as one of the hallmarks of cancer. Furthermore, it is becoming more and more frequent to establish connection between other diseases and metabolic rewiring. One of us has recently argued that metabolic reprogramming is not driven by disease but instead is the main hallmark of metabolism, based on its dynamic behavior that allows it to continuously adapt to changes in the internal and external conditions [1]. Metabolism is considered by many students a remarkably difficult subject, due to its broad contents and the need of integrate them in a biologically meaningful manner. Collaborative learning strategies could contribute to make it easier for students to study metabolism. Since 2015, we design and use problem-based learning (PBL)-like exercises to help our students to study metabolism and its regulation. In the present communication, the experience with a PBL-like exercise devoted to show that reprogramming is a main hallmark of metabolism will be analyzed and discussed. This collaborative learning approach was monitored through comparisons between scores in pre- and post-tests of knowledge, perception and satisfaction questionnaires, evaluation of students’ final reports and final exam scores. Results show an overall high level of satisfaction and higher final exam scores by enrolled students, as compared to those of students that did not take part in these tasks. YR 2023 FD 2023 LK https://hdl.handle.net/10630/27278 UL https://hdl.handle.net/10630/27278 LA eng NO Resumen de la comunicación científica NO This work is supported by an Educative Innovation Project (PIE22-118, funded by University of Málaga). [Grants: PID2022-138181OB-I00, PID2019-105010RB-I00 and RTI2018-098560-BC22 (Spanish Government), UMA18-FEDERJA-220, and PY20_00257 (Andalusian Government and FEDER). Funds from BIO 267 (Andalusian Government)]. M.A.M. requested help form the «II Plan Propio de Investigación, Transference y Divulgación Científica de la UMA», Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech DS RIUMA. Repositorio Institucional de la Universidad de Málaga RD 20 ene 2026