RT Journal Article
T1 Efficacy of the Treatments Used in Multiple Sclerosis: From Meta-analysis to Number Needed to Treat
A1 García-Ruiz, Antonio J.
A1 Izquierdo-Ayuso, Guillermo
A1 Navarro-Mascarell, Guillermo
A1 Montesinos-Gálvez, Ana Carmen
A1 Martos-Crespo, Francisco
A1 Jódar-Sánchez, Francisco
A1 Correa, manuel
A1 García-Agua-Soler, Nuria
K1 Esclerosis múltiple
AB The aim of this study was to analyze the efficacy of drugs used in relapsing-remitting multiple sclerosis, first- and second-line drugs, using the number needed to treat (NNT) as a measure of efficacy.Methods: Data from randomized clinical trials were analyzed for 3 categories of clinical efficacy outcomes: relapse, change in Expanded Disability Status Scale, and number of new lesions in magnetic resonance imaging. Meta-analysis results are expressed as odds ratios.Results: The global odds ratio was 0.41 (95% confidence interval [CI], 0.34-0.49). For analyzed clinical outcomes, the odds ratio was less for second-line drugs (odds ratio, 2.0). For all studied clinical conditions, in the control group, 47 of 100 patients do not get benefits, compared with 25 (95% CI, 18-32 patients) of 100 for the active treatment group. The NNT was 5 patients (95% CI, 4-7 patients). For the proportion of patients free of relapses, in the control group, 56 of 100 patients had a relapse at 2 years, compared with 37 of 100 patients in the treatment group, with an NNT of 6 patients (95% CI, 5-8 patients).Conclusions: Active treatments produced statistically significant improvements compared with placebo.
PB Lippincott Williams & Wilkins
YR 2017
FD 2017-01
LK https://hdl.handle.net/10630/33829
UL https://hdl.handle.net/10630/33829
LA eng
NO García-Ruiz, A. J., Izquierdo-Ayuso, G., Navarro-Mascarell, G., Montesinos-Gálvez, A. C., Martos-Crespo, F., Jódar-Sánchez, F., Correa, M., & García-Agua Soler, N. (2017). Efficacy of the Treatments Used in Multiple Sclerosis: From Meta-analysis to Number Needed to Treat. Clinical neuropharmacology, 40(1), 37–42. https://doi.org/10.1097/WNF.0000000000000201
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 3 mar 2026