RT Journal Article
T1 Longitudinal observation and decline of neutralizing antibody responses in the three months following SARS-CoV-2 infection in humans
A1 Seow, Jeffrey
A1 Graham, Carl
A1 Merrick, Blair
A1 Acors, Sam
A1 Pickering, Suzanne
A1 Steel, Kathryn JA
A1 Hemmings, Oliver
A1 O'Byrne, Aoife
A1 Kouphou, Neophytos
A1 Galao, Rui Pedro
A1 Betancor, Gilberto
A1 Wilson, Harry D
A1 Signell, Adrian W
A1 Winstone, Helena
A1 Kerridge, Claire
A1 Huettner, Isabella
A1 Jimenez-Guardeño, Jose Manuel
A1 Lista, Maria Jose
A1 Temperton, Nigel
A1 Snell, Luke B
A1 Bisnauthsing, Karen
A1 Moore, Amelia
A1 Green, Adrian
A1 Martinez, Lauren
A1 Stokes, Brielle
A1 Honey, Johanna
A1 Izquierdo-Barras, Alba
A1 Arbane, Gill
A1 Patel, Amita
A1 Ik Tan, Mark Kia
A1 O'Connell, Lorcan
A1 O'Hara, Geraldine
A1 MacMahon, Eithne
A1 Douthwaite, Sam
A1 Nebbia, Gaia
A1 Batra, Rahul
A1 Martinez-Nunez, Rocio
A1 Shankar-Hari, Manu
A1 Edgeworth, Jonathan D
A1 Neil, Stuart JD
A1 Malim, Michael H.
A1 Doores, Katie J
K1 Virología
AB Antibody responses to SARS-CoV-2 can be detected in most infected individuals 10-15 d after the onset of COVID-19 symptoms. However, due to the recent emergence of SARS-CoV-2 in the human population, it is not known how long antibody responses will be maintained or whether they will provide protection from reinfection. Using sequential serum samples collected up to 94 d post onset of symptoms (POS) from 65 individuals with real-time quantitative PCR-confirmed SARS-CoV-2 infection, we show seroconversion (immunoglobulin (Ig)M, IgA, IgG) in >95% of cases and neutralizing antibody responses when sampled beyond 8 d POS. We show that the kinetics of the neutralizing antibody response is typical of an acute viral infection, with declining neutralizing antibody titres observed after an initial peak, and that the magnitude of this peak is dependent on disease severity. Although some individuals with high peak infective dose (ID50 > 10,000) maintained neutralizing antibody titres >1,000 at >60 d POS, some with lower peak ID50 had neutralizing antibody titres approaching baseline within the follow-up period. A similar decline in neutralizing antibody titres was observed in a cohort of 31 seropositive healthcare workers. The present study has important implications when considering widespread serological testing and antibody protection against reinfection with SARS-CoV-2, and may suggest that vaccine boosters are required to provide long-lasting protection.
YR 2020
FD 2020
LK https://hdl.handle.net/10630/33869
UL https://hdl.handle.net/10630/33869
LA eng
NO Seow, J., Graham, C., Merrick, B. et al. Longitudinal observation and decline of neutralizing antibody responses in the three months following SARS-CoV-2 infection in humans. Nat Microbiol 5, 1598–1607 (2020). https://doi.org/10.1038/s41564-020-00813-8
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026