RT Journal Article
T1 One-Year Changes in Urinary Microbial Phenolic Metabolites and the Risk of Type 2 Diabetes—A Case-Control Study
A1 Marhuenda-Muñoz, María
A1 Domínguez-López, Inés
A1 Laveriano-Santos, Emily P.
A1 Parilli-Moser, Isabella
A1 Razquin, Cristina
A1 Ruiz-Canela, Miguel
A1 Basterra-Gortari, Francisco Javier
A1 Corella, Dolores
A1 Salas-Salvadó, Jordi
A1 Fitó, Montserrat
A1 Lapetra, José
A1 Arós, Fernando
A1 Fiol, Miquel
A1 Serra-Majem, Lluís
A1 Pintó, Xavier
A1 Gómez-Gracia, Enrique
A1 Ros, Emilio
A1 Estruch, Ramón
A1 Lamuela-Raventós, Rosa M.
K1 Sustancias fitoquímicas
AB The intake of polyphenols has been associated with a risk reduction of type 2 diabetes. Nevertheless, to the best of our knowledge, the molecules that might be metabolically active after ingestion are only starting to be investigated regarding this metabolic disease. To investigate the association between one-year changes in urinary microbial phenolic metabolites (MPM) and the incidence of type 2 diabetes, we performed a case-control study using data and samples of the PREDIMED trial including 46 incident type 2 diabetes cases of 172 randomly selected participants. Eight urinary MPMs were quantified in urine by liquid chromatography coupled to mass spectrometry and used to assess their associations with type 2 diabetes risk by multivariable logistic regression models. Compared to participants in the lowest tertile of one-year changes in hydroxybenzoic acid glucuronide, those in the highest tertile had a significantly lowered probability of developing type 2 diabetes (OR [95% CI], 0.39 [0.23–0.64]; p < 0.001 for trend). However, when additionally adjusting for fasting plasma glucose, the statistical significance was lost. Changes in the dietary pattern can increase the concentrations of this compound, derived from many (poly)phenol-rich foods, and might be changing the gut microbial population as well, promoting the production of the metabolite.
PB IOAP-MPDI
YR 2022
FD 2022-08
LK https://hdl.handle.net/10630/24826
UL https://hdl.handle.net/10630/24826
LA eng
NO Marhuenda-Muñoz M, Domínguez-López I, Laveriano-Santos EP, Parilli-Moser I, Razquin C, Ruiz-Canela M, Basterra-Gortari FJ, Corella D, Salas-Salvadó J, Fitó M, Lapetra J, Arós F, Fiol M, Serra-Majem L, Pintó X, Gómez-Gracia E, Ros E, Estruch R, Lamuela-Raventós RM. One-Year Changes in Urinary Microbial Phenolic Metabolites and the Risk of Type 2 Diabetes—A Case-Control Study. Antioxidants. 2022; 11(8):1540. https://doi.org/10.3390/antiox11081540
NO This research was funded by CICYT [AGL2016-75329-R] PID2020-114022RB-I00, CIBEROBN Instituto de Salud Carlos III, ISCIII from the Ministerio de Ciencia, Innovación y Universidades, (AEI/FEDER 10.13039/501100011033, UE), and Generalitat de Catalunya (GC) [2017SGR196]. M.M.-M. is supported by the FPU17/00513 grant. I.D.-L. thanks the Spanish Ministry of Science Innovation and Universities for the Formación de Profesorado Universitario (FPU20/02478) contract. E.P.L.-S. is supported by the FI-SDUR (EM/3345/2020) grant from the Generalitat de Catalunya. I.P.-M. is supported by the FI-SDUR (EMC/2703/2019). Partial funding for open access charge: Universidad de Málaga.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026