RT Journal Article
T1 A Proteomic Study of the Bioactivity of Annona muricata Leaf Extracts in HT-1080 Fibrosarcoma Cells.
A1 Marrero Capitán, Ana Dácil
A1 Rodríguez-Quesada, Ana María
A1 Martínez-Póveda, Beatriz Amparo
A1 Medina-Torres, Miguel Ángel
A1 Cárdenas, Casimiro
K1 Cáncer - Investigación
K1 Frutas tropicales -  Uso terapéutico - Ensayos
K1 Anonáceas - Uso terapéutico - Ensayos
AB Graviola (Annona muricata) is a tropical plant with many traditional ethnobotanic usesand pharmacologic applications. A metabolomic study of both aqueous and DMSO extracts fromAnnona muricata leaves recently allowed us to identify dozens of bioactive compounds. In the presentstudy, we use a proteomic approach to detect altered patterns in proteins on both conditioned mediaand extracts of HT-1080 fibrosarcoma cells under treatment conditions, revealing new potentialbioactivities of Annona muricata extracts. Our results reveal the complete sets of deregulated proteinsafter treatment with aqueous and DMSO extracts from Annona muricata leaves. Functional enrichmentanalysis of proteomic data suggests deregulation of cell cycle and iron metabolism, which areexperimentally validated in vitro. Additional experimental data reveal that DMSO extracts protectHT-1080 fibrosarcoma cells and HMEC-1 endothelial cells from ferroptosis. Data from our proteomicstudy are available via ProteomeXchange with identifier PXD042354.
PB MDPI
YR 2023
FD 2023-07-27
LK https://hdl.handle.net/10630/31652
UL https://hdl.handle.net/10630/31652
LA eng
NO Marrero, A. D., Quesada, A. R., Martínez-Poveda, B., Medina, M. Á., & Cárdenas, C. (2023). A Proteomic Study of the Bioactivity of Annona muricata Leaf Extracts in HT-1080 Fibrosarcoma Cells. International Journal Of Molecular Sciences, 24(15), 12021. https://doi.org/10.3390/ijms241512021
NO Partial funding for open access charge: Universidad de Málaga
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026