RT Journal Article
T1 Continuous Positive Airway Pressure Treatment in Patients with Alzheimer’s Disease: A Systematic Review.
A1 Pérez-Cabezas, Verónica
A1 Ruiz-Molinero, Carmen
A1 Jiménez-Rejano, José-Jesús
A1 González-Medina, Gloria
A1 Galán Mercant, Alejandro
A1 Martín-Valero, Rocío
K1 Alzheimer, Enfermedad de
K1 Síndrome de apnea del sueño
AB Background: Epidemiological studies have suggested a pathophysiological relationship between obstructive sleep apnea syndrome (OSAS) and Alzheimer’s disease (AD). The aim of this study is to evaluate the treatment of obstructive sleep apnea with continuous positive airway pressure (CPAP) in AD and its relationship with neurocognitive function improvement. Methods: Systematic review conducted following PRISMA’s statements. Relevant studies were searched in MEDLINE, PEDro, SCOPUS, PsycINFO, Web of Science, CINAHL and SportDicus. Original studies in which CPAP treatment was developel in AD patients have been included. Results: 5 studies, 3 RCTs (Randomized controlled trials) and 2 pilot studies. In all RCTs the CPAP intervention was six weeks; 3 weeks of therapeutic CPAP vs. 3 weeks placebo CPAP (pCPAP) followed by 3 weeks tCPAP in patients with AD and OSA. The two pilot studies conducted a follow-up in which the impact on cognitive impairment was measured. Conclusions: CPAP treatment in AD patients decreases excessive daytime sleepiness and improves sleep quality. There are indications that cognitive deterioration function measured with the Mini Mental Scale decreases or evolves to a lesser extent in Alzheimer’s patients treated with CPAP. Caregivers observe stabilization in disease progression with integration of CPAP. More research is needed on the topic presented.
PB MDPI
YR 2020
FD 2020
LK https://hdl.handle.net/10630/35277
UL https://hdl.handle.net/10630/35277
LA eng
NO Perez-Cabezas, V.; Ruiz-Molinero, C.; Jimenez-Rejano, J.J.; Gonzalez-Medina, G.; Galan-Mercant, A.; Martin-Valero, R. Continuous Positive Airway Pressure Treatment in Patients with Alzheimer’s Disease: A Systematic Review. J. Clin. Med. 2020, 9, 181. https://doi.org/10.3390/jcm9010181
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 25 ene 2026