RT Journal Article
T1 Brains from non-Alzheimer’s individuals containing amyloid deposits accelerate Aβ deposition in vivo.
A1 Duran-Aniotz, Claudia
A1 Morales, Rodrigo
A1 Moreno-González, Inés
A1 Hu, Ping Ping
A1 Soto, Claudio
K1 Alzheimer, Enfermedad de
K1 Modelos animales en investigación
AB Background: One of the main features of Alzheimer’s disease (AD) is the presence of Aβ deposits, whichaccumulate in the brain years before the onset of symptoms. We and others have demonstrated that cerebralAβ-amyloidosis can be induced in vivo by administration of AD-brain extracts into transgenic mice. However, it iscurrently unknown whether amyloid formation can be induced using extracts from individuals harboring Aβdeposits, but not clinical disease.Results: In this study we analyzed the amyloid-inducing capability of samples from individuals affected by mildcognitive impairment (MCI) and Non-Demented persons with Alzheimer’s disease Neuropathology (NDAN). Ourresults show that inoculation of transgenic mice with MCI and NDAN brain samples accelerated Aβ pathology in asimilar way as extracts from confirmed AD.Conclusions: This data demonstrate that the sole presence of Aβ aggregates in a given sample, regardless of theclinical condition, is capable to accelerate Aβ deposition in vivo. These findings indicate that the amyloid-inducingactivity may be present in the brain of people during pre-symptomatic or a-symptomatic stages of AD.
PB BMC
YR 2013
FD 2013-11-18
LK https://hdl.handle.net/10630/36991
UL https://hdl.handle.net/10630/36991
LA eng
NO Duran-Aniotz, C., Morales, R., Moreno-Gonzalez, I., Hu, P. P., & Soto, C. (2013). Brains from non-Alzheimer’s individuals containing amyloid deposits accelerate Aβ deposition in vivo. Acta Neuropathologica Communications, 2(1).
NO This work was partially funded by an award from the Mitchell Foundation to C.S. and a Grant from the Alzheimer’s Association (MNIRGD-12-243075) to R.M.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026