RT Journal Article T1 Acute kidney injury: Renal disease in the ICU. A1 Seller Pérez, Gemma Luisa A1 Mas Font, Sonia A1 Pérez Calvo, C. A1 Villa Díaz, Patricia A1 Celaya López, Mikel A1 Herrera-Gutiérrez, Manuel Enrique K1 Insuficiencia renal aguda K1 Cuidados intensivos K1 Biomarcadores AB Acute kidney injury (AKI) in the ICU frequently requires costly supportive therapies, has high morbidity, and its long-term prognosis is not as good as it has been presumed so far. Consequently, AKI generates a significant burden for the healthcare system. The problem is that AKI lacks an effective treatment and the best approach relies on early secondary prevention. Therefore, to facilitate early diagnosis, a broader definition of AKI should be established, and a marker with more sensitivity and early-detection capacity than serum creatinine - the most common marker of AKI - should be identified. Fortunately, new classification systems (RIFLE, AKIN or KDIGO) have been developed to solve these problems, and the discovery of new biomarkers for kidney injury will hopefully change the way we approach renal patients. As a first step, the concept of renal failure has changed from being a "static" disease to being a "dynamic process" that requires continuous evaluation of kidney function adapted to the reality of the ICU patient. PB Elsevier YR 2016 FD 2016-08 LK https://hdl.handle.net/10630/41322 UL https://hdl.handle.net/10630/41322 LA eng NO Seller-Pérez G, Más-Font S, Pérez-Calvo C, Villa-Díaz P, Celaya-López M, Herrera-Gutiérrez ME. Acute kidney injury: Renal disease in the ICU. Med Intensiva. 2016 Aug-Sep;40(6):374-82. English, Spanish. doi: 10.1016/j.medin.2016.05.002. Epub 2016 Jul 4. PMID: 27388683. DS RIUMA. Repositorio Institucional de la Universidad de Málaga RD 21 ene 2026