RT Journal Article
T1 Human Pluripotent Stem Cell-Derived Neural Cells as a Relevant Platform for Drug Screening in Alzheimer’s Disease.
A1 García-León, Juan Antonio
A1 Cáceres Palomo, Laura
A1 Sánchez-Mejías, Elisabeth
A1 Mejías-Ortega, Marina
A1 Núñez-Díaz, Cristina
A1 Fernández-Valenzuela, Juan José
A1 Sánchez-Varo, Raquel María
A1 Dávila-Cansino, José Carlos
A1 Vitorica Ferrández, Javier
A1 Gutiérrez-Pérez, Antonia
K1 Alzheimer, Enfermedad de
K1 Células madre - Investigación
K1 Oligodendroglia
AB Extracellular amyloid-beta deposition and intraneuronal Tau-laden neurofibrillary tangles are prime features of Alzheimer’s disease (AD). The pathology of AD is very complex and still not fully understood, since different neural cell types are involved in the disease. Although neuronal function is clearly deteriorated in AD patients, recently, an increasing number of evidences have pointed towards glial cell dysfunction as one of the main causative phenomena implicated in AD pathogenesis. The complex disease pathology together with the lack of reliable disease models have precluded the development of effective therapies able to counteract disease progression. The discovery and implementation of human pluripotent stem cell technology represents an important opportunity in this field, as this system allows the generation of patient-derived cells to be used for disease modeling and therapeutic target identification and as a platform to be employed in drug discovery programs. In this review, we discuss the current studies using human pluripotent stem cells focused on AD, providing convincing evidences that this system is an excellent opportunity to advance in the comprehension of AD pathology, which will be translated to the development of the still missing effective therapies.
PB MDPI
YR 2020
FD 2020-09-18
LK https://hdl.handle.net/10630/31849
UL https://hdl.handle.net/10630/31849
LA eng
NO Garcia-Leon JA, Caceres-Palomo L, Sanchez-Mejias E, Mejias-Ortega M, Nuñez-Diaz C, Fernandez-Valenzuela JJ, Sanchez-Varo R, Davila JC, Vitorica J, Gutierrez A. Human Pluripotent Stem Cell-Derived Neural Cells as a Relevant Platform for Drug Screening in Alzheimer's Disease. Int J Mol Sci. 2020 Sep 18;21(18):6867. doi: 10.3390/ijms21186867. PMID: 32962164; PMCID: PMC7558359.
NO Instituto de Salud Carlos III (ISCiii) de España, cofinanciado por fondos FEDER de la Union Europea ref. PI18/01557 (AG), ref. PI18/01556 (JV).CIBERNED (ref. CB06/05/1116 para AG; ref. CB06/05/0094 para JV).Junta de Andalucia, Consejería de Economía y Conocimiento ref. UMA18-FEDERJA-211 (AG), PY18-RT-2233 (AG) and US-1262734 (JV) co-financiado por Programa Operativo FEDER 2014-2020 y Consejeria de Salud ref. PI-0276-2018 (JAGL).Ayuda a proyectos de Jóvenes Investigadores de la Universidad de Málaga ref. PPIT.UMA.B1.2017/26 (RSV). JJFV - beca FPU del Ministerio Español de Ciencia, Innovación y Universidades.RSV y MMO -  contrato postdoctoral y predoctoral de la Universidad de Málaga, respectivamente.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026